Heavy metals and fertility
Heavy metals and fertility
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DOI：
10.1080/009841098158638
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发表时间：
1998-08-21
影响因子：
2.6
通讯作者：
Runnebaum, B
中科院分区：
文献类型：
--
作者：
Gerhard, I;Monga, B;Runnebaum, B
重金属已被确定为影响人类生育能力的因素。本研究旨在探讨尿液重金属排泄量是否与不同的不孕因素相关。测定了 501 名不孕妇女口服螯合剂 2,3-二巯基丙烷-1-磺酸 (DMPS) 后的尿重金属排泄量。此外，还研究了微量元素和维生素给药对金属排泄的影响。研究发现不同重金属与临床参数（年龄、体重指数、国籍）以及妇科疾病（子宫肌瘤、流产、荷尔蒙失调）之间存在显着相关性。诊断和减少重金属身体负荷增加提高了不孕妇女自然受孕的机会。 DMPS 测试是一种有用且补充的诊断方法。充分的治疗为传统激素疗法提供了成功的替代方案。
Heavy metals have been identified as factors affecting human fertility. This study was designed to investigate whether the urinary heavy metal excretion is associated with different factors of infertility. The urinary heavy metal excretion was determined in 501 infertile women after oral administration of the chelating agent 2,3-dimercaptopropane-1-sulfonic acid (DMPS). Furthermore, the influence of trace element and vitamin administration on metal excretion was investigated. Significant correlations were found between different heavy metals and clinical parameters (age, body mass index, nationality) as well as gynecological conditions (uterine fibroids, miscarriages, hormonal disorders). Diagnosis and reduction of an increased heavy metal body load improved the spontaneous conception chances of infertile women. The DMPS test was a useful and complementary diagnostic method. Adequate treatment provides successful alternatives to conventional hormonal therapy.