Adult T-Cell Leukemia/Lymphoma
Adult T-Cell Leukemia/Lymphoma
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DOI：
10.5858/arpa.2012-0379-rs
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发表时间：
2014-02-01
影响因子：
4.6
通讯作者：
Choi, John K.
中科院分区：
文献类型：
--
作者：
Qayyum, Sohail;Choi, John K.
成人t细胞白血病/淋巴瘤是一种罕见的成熟CD4(+) t细胞肿瘤，由人t淋巴营养病毒1型逆转录病毒引起。目前，全球约有2000万人感染了这种病毒，其中大多数人属于日本南部、非洲、加勒比盆地和拉丁美洲的流行地区。在美国，它通常见于来自这些流行地区的移民。成人t细胞白血病/淋巴瘤主要影响成人人群，在儿童中很少见。成人t细胞白血病/淋巴瘤有4种亚型：急性、淋巴瘤、慢性和阴燃型。临床上，前两种变异被归类为侵袭性，后两种被归类为惰性。鉴于与成人t细胞白血病/淋巴瘤相关的罕见发生和诊断挑战，本综述将突出其显著特征，以帮助识别这种实体并进行全面的诊断检查。
Adult T-cell leukemia/lymphoma is a rare mature CD4(+) T-cell neoplasm caused by the retrovirus human T-lymphotrophic virus type 1. At present there are approximately 20 million people infected globally with this virus, and most of these individuals belong to the endemic areas in southern Japan, Africa, the Caribbean basin, and Latin America. In the United States, it is usually seen in immigrants from these endemic regions. Adult T-cell leukemia/lymphoma predominantly affects the adult population and is rare in children. Adult T-cell leukemia/lymphoma has 4 subtypes: acute, lymphomatous, chronic, and smoldering. Clinically, the first 2 variants are classified as aggressive, and the latter two are classified as indolent. Given the rare occurrence and diagnostic challenges associated with adult T-cell leukemia/lymphoma, this review will highlight its salient features to aid in recognition of this entity and perform a comprehensive diagnostic workup.