Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections
Hydrogen peroxide-producing lactobacilli and acquisition of vaginal infections
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DOI：
10.1093/infdis/174.5.1058
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发表时间：
1996-11-01
影响因子：
6.4
通讯作者：
Holmes, KK
中科院分区：
文献类型：
--
作者：
Hawes, SE;Hillier, SL;Holmes, KK
这项对182名参加性传播疾病诊所的妇女进行的队列研究评估了乳酸杆菌定植的妇女减少阴道感染的假设。在2年的随访中，50名妇女获得细菌性阴道病（BV），25名获得症状性外阴阴道念珠菌病（VVC），7名获得阴道滴虫病。通过多变量分析，利用时间依赖性协变量的考克斯比例风险模型，BV的获得与阴道缺乏产生H2O2的乳酸杆菌独立相关（风险比[HR] = 4.0，P <0.001）或仅存在不产生H2O2的乳酸杆菌（HR = 2.2，P = 0.02），BV的获得与有新的性伴侣（HR = 2.5，P = 0.004）和冲洗卫生（HR = 2.1，P = 0.05）相关。缺乏乳酸杆菌并没有增加VVC的获得。滴虫病仅与有新的性伴侣有关（HR = 4.7，P = 0.05）。这些结果支持了产生H2O2的阴道乳酸杆菌防止BV获得但不防止WC或阴道滴虫病的假设。
This cohort study of 182 women attending a sexually transmitted disease clinic evaluated the hypothesis that women colonized by lactobacilli have decreased acquisition of vaginal infections. During a 2-year follow-up, 50 women acquired bacterial vaginosis (BV), 25 acquired symptomatic vulvovaginal candidiasis (VVC), and 7 acquired vaginal trichomoniasis. By multivariate analysis, utilizing Cox proportional hazards modeling with time-dependent covariates, acquisition of BV was independently associated with lack of vaginal H2O2-producing lactobacilli (hazard ratio [HR] = 4.0, P < .001) or presence of only non-H2O2-producing lactobacilli (HR = 2.2, P = .02), Acquisition of BV was associated with having a new sex partner (HR = 2.5, P = .004) and with douching for hygiene (HR = 2.1, P = .05). Absence of lactobacilli did not increase acquisition of VVC. Trichomoniasis was associated only with having a new sex partner (HR = 4.7, P = .05), These results support the hypothesis that H2O2-producing vaginal lactobacilli protect against acquisition of BV hut do not protect against WC or vaginal trichomoniasis.