Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation
Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation
复制标题
丘脑前内侧核到前扣带皮层的输入调节组胺能瘙痒感
DOI：
10.1016/j.neuropharm.2020.108028
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发表时间：
2020-05-15
影响因子：
4.7
通讯作者：
Liu, Jing-Gen
中科院分区：
文献类型：
--
作者：
Deng, Ying-Zhi;Lu, Yu-Chen;Liu, Jing-Gen
瘙痒是一种不舒服的感觉，会引发抓挠行为。在外周和脊髓水平上识别瘙痒的机制方面已经取得了很大的进展，然而，大脑中的瘙痒回路在很大程度上仍然没有被探索。我们以前发现，前扣带回皮质(ACC)到背侧内侧纹状体(DMS)的传入调制了组胺引起的瘙痒感觉，但瘙痒信息是如何传递到ACC的尚不清楚。在此，我们证实了组胺能瘙痒时丘脑前内侧核(AM)被激活，并且AM和ACC之间存在相互的神经元投射。切断AM和ACC之间的连接可显著减少组胺能，但不能减少非组胺能瘙痒相关的抓挠行为。AM-ACC的光遗传激活，而不是ACC-AM的投射引起组胺能瘙痒感觉。因此，我们的研究首次揭示了AM对组胺能瘙痒感觉的关键作用，AM-ACC投射调控组胺能瘙痒行为。
Itch is an unpleasant feeling that triggers scratching behavior. Much progress has been made in identifying the mechanism of itch at the peripheral and spinal levels, however, itch circuits in the brain remain largely unexplored. We previously found that anterior cingulate cortex (ACC) to dorsal medial striatum (DMS) inputs modulated histamine-induced itch sensation, but how itch information was transmitted to ACC remained unclear. Here, we demonstrated that the anteromedial thalamic nucleus (AM) was activated during histaminergic itch, and there existed reciprocal neuronal projections between AM and ACC. Disconnection between AM and ACC resulted in a significant reduction of histaminergic, but not nonhistaminergic, itch-related scratching behavior. Optogenetic activation of AM-ACC, but not ACC-AM, projections evoked histaminergic itch sensation. Thus, our studies firstly reveal that AM is critical for histaminergic itch sensation and AM-ACC projections modulate histaminergic itch-induced scratching behavior.