Rapidly regulated genes are intron poor
Rapidly regulated genes are intron poor
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DOI：
10.1016/j.tig.2008.05.006
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发表时间：
2008-08-01
影响因子：
11.4
通讯作者：
Baehler, Juerg
中科院分区：
文献类型：
--
作者：
Jeffares, Daniel C.;Penkett, Christopher J.;Baehler, Juerg
我们发现，在酵母、水芹和小鼠中，表达水平对应激反应迅速变化的基因含有显著较低的内含子密度。因此，我们认为内含子可以延迟调控反应，并在转录需要快速调整以应对环境挑战的基因中进行选择。这些发现可能为某些真核生物谱系进化过程中明显的广泛内含子丢失提供解释。
We show that genes with rapidly changing expression levels in response to stress contain significantly lower intron densities in yeasts, thale cress and mice. Therefore, we propose that introns can delay regulatory responses and are selected against in genes whose transcripts require rapid adjustment for survival of environmental challenges. These findings could provide an explanation for the apparent extensive intron loss during the evolution of some eukaryotic lineages.