Low-voltage electroosmosis pump for stand-alone microfluidics devices
Low-voltage electroosmosis pump for stand-alone microfluidics devices
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DOI：
10.1002/elps.200390012
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发表时间：
2003-01-01
期刊：
影响因子：
2.9
通讯作者：
Horiike, Y
中科院分区：
文献类型：
--
作者：
Takamura, Y;Onoda, H;Horiike, Y
两种类型的低电压电渗泵的开发使用微制造技术，用于方便或独立的应用程序的微全分析系统（mu-TAS）和芯片实验室。这是通过在流路中形成薄（< 1 μ m）区域，并通过使用插入流路中的电极仅在该薄区域附近施加电压来实现的。对于这些电极，使用Ag/AgCl或凝胶盐桥。为了在芯片上图案化凝胶，亲水性光聚合凝胶和光刻技术被优化以产生具有更高导电性和更高机械强度的凝胶。对于高流速应用，通过折叠将宽（33.2mm）和薄（400 nm）泵送通道压缩成1 mm × 6 mm的区域。该泵在10 V下实现800 Pa的静压和415 nL/min的流量。对于高压应用，泵被设计成具有串联的薄区域和厚区域，并且在它们之间交替地插入正电极和负电极。该泵可以在不增加电源电压的情况下增加泵送压力。具有10级连接的泵在10 V下产生25 kPa的压力。
Two types of low-voltage electroosmosis pumps were developed using microfabrication technology for usage in handy or stand-alone applications of the micrototal analysis systems (mu-TAS) and the lab-on-a-chip. This was done by making a thin (< 1 mum) region in the flow path and by only applying voltages near this thin region using electrodes inserted into the flow path. The inserted electrodes must be free from bubble formation and be gas-tight in order to avoid pressure leakage. For these electrodes, Ag/AgCl or a gel salt bridge was used. For patterning the gel on the chip, a hydrophilic photopolymerization gel and a photolithographic technique were optimized for producing a gel with higher electric conductivity and higher mechanical strength. For high flow rate application, wide (33.2 mm) and thin (400 nm) pumping channels were compacted into a 1 mm x 6 mm area by folding. This pump achieves an 800 Pa static pressure and a flow of 415 nL/min at 10 V. For high-pressure application, a pump was designed with the thin and thick regions in series and positive and negative electrodes were inserted between them alternatively. This pump could increase the pumping pressure without increasing the supply voltage. A pump with 10-stage connections generated a pressure of 25 kPa at 10 V.