Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment.
Molecular Mechanisms and Biological Functions of Autophagy for Genetics of Hearing Impairment.
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DOI：
10.3390/genes11111331
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发表时间：
2020-11-11
期刊：
影响因子：
3.5
通讯作者：
Kanzaki S
中科院分区：
文献类型：
--
作者：
Hayashi K;Suzuki Y;Fujimoto C;Kanzaki S
耳蜗损伤后听力障碍的病因可能由许多因素引起，包括先天性或获得性发作、耳毒性药物、噪声暴露和衰老。尽管有许多不同的病因，一个共同的病理变化是听觉细胞死亡。由于听力损失的程度差异很大，仅从细胞死亡（包括凋亡、坏死或坏死性凋亡）的角度来解释听力损失可能是困难的。因此，我们将自噬作为一种功能上与细胞死亡竞争的细胞内现象。自噬是真核细胞中的一种动态溶酶体降解和再循环系统，对于控制由细胞应激诱导的细胞存活和细胞死亡之间的平衡以及维持有丝分裂后细胞（包括内耳中的毛细胞（HC）和螺旋神经节神经元（SGN））的稳态是必需的。自噬被认为是听觉细胞命运决定因素的候选者，而自噬缺陷可能是听力障碍的主要原因之一。本文综述了听觉系统自噬的分子机制和生物学功能，并讨论了自噬相关基因和感音神经性听力损失的最新研究，以深入了解自噬机制在内耳疾病中的作用。
The etiology of hearing impairment following cochlear damage can be caused by many factors, including congenital or acquired onset, ototoxic drugs, noise exposure, and aging. Regardless of the many different etiologies, a common pathologic change is auditory cell death. It may be difficult to explain hearing impairment only from the aspect of cell death including apoptosis, necrosis, or necroptosis because the level of hearing loss varies widely. Therefore, we focused on autophagy as an intracellular phenomenon functionally competing with cell death. Autophagy is a dynamic lysosomal degradation and recycling system in the eukaryotic cell, mandatory for controlling the balance between cell survival and cell death induced by cellular stress, and maintaining homeostasis of postmitotic cells, including hair cells (HCs) and spiral ganglion neurons (SGNs) in the inner ear. Autophagy is considered a candidate for the auditory cell fate decision factor, whereas autophagy deficiency could be one of major causes of hearing impairment. In this paper, we review the molecular mechanisms and biologic functions of autophagy in the auditory system and discuss the latest research concerning autophagy-related genes and sensorineural hearing loss to gain insight into the role of autophagic mechanisms in inner-ear disorders.
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影响因子：
11.4
作者：
Fetoni AR;Zorzi V;Paciello F;Ziraldo G;Peres C;Raspa M;Scavizzi F;Salvatore AM;Crispino G;Tognola G;Gentile G;Spampinato AG;Cuccaro D;Guarnaccia M;Morello G;Van Camp G;Fransen E;Brumat M;Girotto G;Paludetti G;Gasparini P;Cavallaro S;Mammano F
通讯作者：
Mammano F
影响因子：
2
作者：
Escobar LI;Simian C;Treard C;Hayek D;Salvador C;Guerra N;Matos M;Medeiros M;Enciso S;Camargo MD;Vargas-Poussou R
通讯作者：
Vargas-Poussou R
影响因子：
3.5
作者：
Dubos A;Castells-Nobau A;Meziane H;Oortveld MA;Houbaert X;Iacono G;Martin C;Mittelhaeuser C;Lalanne V;Kramer JM;Bhukel A;Quentin C;Slabbert J;Verstreken P;Sigrist SJ;Messaddeq N;Birling MC;Selloum M;Stunnenberg HG;Humeau Y;Schenck A;Herault Y
通讯作者：
Herault Y
DOI：
10.1073/pnas.1821844116
发表时间：
2019-04-16
影响因子：
11.1
作者：
Defourny, Jean;Aghaie, Alain;Petit, Christine
通讯作者：
Petit, Christine
影响因子：
9.8
作者：
Haack, Tobias B.;Hogarth, Penelope;Hayflick, Susan J.
通讯作者：
Hayflick, Susan J.