THE REQUIREMENT FOR FERRIC IN THE INITIATION OF LIPID-PEROXIDATION BY CHELATED FERROUS IRON
THE REQUIREMENT FOR FERRIC IN THE INITIATION OF LIPID-PEROXIDATION BY CHELATED FERROUS IRON
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DOI：
10.1016/0006-291x(83)91366-9
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发表时间：
1983-01-01
影响因子：
3.1
通讯作者：
AUST, SD
中科院分区：
文献类型：
--
作者：
BUCHER, JR;TIEN, M;AUST, SD
当某些Fe 2+螯合物被添加到脂质中时，脂质的过氧化反应在短暂的滞后后发生。这表明需要Fe 2+自氧化的产物来启动脂质过氧化。这种自氧化产物显然是Fe 3+，而不是也由亚铁自氧化产生的氧自由基。用氧自由基清除剂和过氧化氢酶的研究表明，H2 O2，.图形 **。或OH不参与引发反应，因此Fe 2 +-二氧-Fe 3+螯合物可以是引发物质。
When certain Fe2+ chelates are added to lipid, peroxidation of the lipid occurs following a short lag. This suggests that a product of Fe2+ autoxidation is required to initiate lipid peroxidation. This autoxidation product is apparently Fe3+, rather than the oxygen radicals which also result from ferrous autoxidation. Studies with oxy-radical scavengers and catalase suggest that H202, .**GRAPHIC**. or the .cntdot.OH are not involved in the initiation reactions, therefore a Fe2+-dioxygen-Fe3+ chelate complex may be the initiating species.