CELL-SURFACE PEPTIDASES AS MODULATORS OF GROWTH AND DIFFERENTIATION

CELL-SURFACE PEPTIDASES AS MODULATORS OF GROWTH AND DIFFERENTIATION
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细胞表面肽酶作为生长和分化的调节剂

DOI:
10.1016/s0140-6736(89)90841-6
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发表时间:
1989
期刊:
The Lancet
影响因子:
--
通讯作者:
B. Gusterson
B. Gusterson
中科院分区:
--
文献类型:
--
作者:
A. Kenny;M. O'Hare;B. Gusterson

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由CD(簇分化)命名法定义的许多细胞表面抗原中的一些最近出现了具有良好表征的酶活性的蛋白质。一个重要的例子是CD 10或CALLA(常见的急性淋巴细胞白血病抗原),其与内肽酶-24.11相同,内肽酶-24.11是一种在生物活性肽的水解中具有重要作用的酶。CD 13和CD 26也是表面肽酶。这些酶广泛分布于各种细胞类型的表面,可能在造血和上皮细胞系统的生长和分化的控制中具有特定的作用。
Some of the many cell-surface antigens defined by the CD (cluster differentiation) nomenclature have lately emerged as proteins with well-characterised enzymic activities. One important example is CD10 or CALLA (common acute lymphoblastic leukaemia antigen), which is identical to endopeptidase-24.11, an enzyme with an important role in the hydrolysis of biologically active peptides. CD13 and CD26 are also surface peptidases. These enzymes, which have a wide distribution on the surfaces of various cell types, may have specific roles in the control of growth and differentiation in both haemopoietic and epithelial cell systems.
DOI: 10.1172/jci114015
发表时间: 1989-04-01
影响因子: 15.9
作者:
LOOK, AT;ASHMUN, RA;PEIPER, SC
通讯作者: PEIPER, SC