NK cells negatively regulate antigen presentation and tumor-specific CTLs in a syngeneic lymphoma model
NK cells negatively regulate antigen presentation and tumor-specific CTLs in a syngeneic lymphoma model
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DOI：
10.4049/jimmunol.178.10.6140
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发表时间：
2007-05-15
影响因子：
4.4
通讯作者：
Sentman, Charles L.
中科院分区：
文献类型：
--
作者：
Barber, Melissa A.;Zhang, Tong;Sentman, Charles L.
已知NK细胞杀死肿瘤细胞并产生导致肿瘤特异性CTL产生的促炎细胞因子。许多研究使用了MHC I类缺陷型肿瘤细胞和/或诱导NK细胞应答的佐剂。在这项研究中，重点是表达MHC I类的免疫原性较低的淋巴瘤细胞作为研究NK细胞对不直接刺激NK细胞活化的肿瘤的反应的模型。当将表达截短形式的OVA的RMA肿瘤细胞或单独的RMA细胞注射到NK细胞耗尽的小鼠中时，与具有完整NK细胞的小鼠相比，小鼠产生了肿瘤特异性CTL数量增加、IFN-γ应答增加以及引流LN中Ag呈递量更高。这些数据表明，在缺乏触发NK细胞活化的信号的情况下，NK细胞可以抑制有效的适应性免疫的发展。免疫学杂志，2007，178：6140-6147.
NK cells are known to kill tumor cells and produce proinflammatory cytokines that lead to the generation of tumor-specific CTLs. Many studies have used MHC class I-deficient tumor cells and/or adjuvants that induce NK cell responses. In this study, the focus was on less-immunogenic lymphoma cells that express MHC class I as a model to study NK cell responses to tumors that do not directly stimulate NK cell activation. When RMA tumor cells that expressed a truncated version of OVA, or RMA cells alone, were injected into mice that were depleted of NK cells, the mice developed an increased number of tumor-specific CTLs, increased IFN-gamma responses, and a higher amount of Ag presentation in draining LNs compared with mice with intact NK cells. These data suggest that NK cells can inhibit the development of effective adaptive immunity in the absence of signals that trigger NK cell activation. The Journal of Immunology, 2007, 178: 6140-6147.