Smoking Cessation After Lung Cancer Diagnosis and the Risk of Second Primary Lung Cancer: The Multiethnic Cohort Study.
Smoking Cessation After Lung Cancer Diagnosis and the Risk of Second Primary Lung Cancer: The Multiethnic Cohort Study.
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DOI：
10.1093/jncics/pkab076
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发表时间：
2021-10
影响因子：
4.4
通讯作者：
Han SS
中科院分区：
文献类型：
--
作者：
Luo SJ;Choi E;Aredo JV;Wilkens LR;Tammemägi MC;Le Marchand L;Cheng I;Wakelee HA;Han SS
戒烟可降低肺癌死亡率。然而，对于肺癌的诊断是否会影响吸烟行为的改变，人们知之甚少。此外，戒烟对第二原发性肺癌（SPLC）风险的影响尚未确定。本研究旨在探讨原发性肺癌（IPLC）诊断后吸烟行为的改变，并评估戒烟对IPLC诊断后SPLC风险的影响。该研究队列由986名多民族队列研究的参与者组成，他们在基线（1993-1996年）无肺癌和活跃吸烟者，提供了10年的随访吸烟数据（2003-2008年），并在1993-2017年被诊断为IPLC。主要结局是吸烟状况从基线时的“当前”改变为10年随访时的“既往”（即戒烟），使用逻辑回归进行分析。第二个结果是戒烟后的SPLC发病率，使用病因特异性Cox回归估计。所有统计检验均为双侧检验。在基线时的986名吸烟者中，51.1%的人在10年随访中报告戒烟。在基线和10年随访期间，诊断为IPLC的戒烟率（80.6%）高于未诊断为IPLC的戒烟率（45.4%）（校正优势比= 5.12,95%可信区间[CI] = 3.38 ~ 7.98; P < .001）。504名在随访中报告戒烟的参与者与未戒烟的参与者相比，SPLC的发病率有统计学意义上的显著降低（校正风险比= 0.31,95% CI = 0.14 ~ 0.67; P = 0.003）。肺癌诊断对戒烟有统计学上显著的影响。IPLC诊断后戒烟可降低随后肺部恶性肿瘤发生的风险。
Smoking cessation reduces lung cancer mortality. However, little is known about whether diagnosis of lung cancer impacts changes in smoking behaviors. Furthermore, the effects of smoking cessation on the risk of second primary lung cancer (SPLC) have not been established yet. This study aims to examine smoking behavior changes after initial primary lung cancer (IPLC) diagnosis and estimate the effect of smoking cessation on SPLC risk following IPLC diagnosis. The study cohort consisted of 986 participants in the Multiethnic Cohort Study who were free of lung cancer and active smokers at baseline (1993-1996), provided 10-year follow-up smoking data (2003-2008), and were diagnosed with IPLC in 1993-2017. The primary outcome was a change in smoking status from “current” at baseline to “former” at 10-year follow-up (ie, smoking cessation), analyzed using logistic regression. The second outcome was SPLC incidence after smoking cessation, estimated using cause-specific Cox regression. All statistical tests were 2-sided. Among 986 current smokers at baseline, 51.1% reported smoking cessation at 10-year follow-up. The smoking cessation rate was statistically significantly higher (80.6%) for those diagnosed with IPLC between baseline and 10-year follow-up vs those without IPLC diagnosis (45.4%) during the 10-year period (adjusted odds ratio = 5.12, 95% confidence interval [CI] = 3.38 to 7.98; P < .001). Incidence of SPLC was statistically significantly lower among the 504 participants who reported smoking cessation at follow-up compared with those without smoking cessation (adjusted hazard ratio = 0.31, 95% CI = 0.14 to 0.67; P = .003). Lung cancer diagnosis has a statistically significant impact on smoking cessation. Quitting smoking after IPLC diagnosis may reduce the risk of developing a subsequent malignancy in the lungs.
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流行病学和临床研究中缺少数据的多重归因：潜力和陷阱。
DOI：
10.1136/bmj.b2393
发表时间：
2009-06-29
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Sterne JA;White IR;Carlin JB;Spratt M;Royston P;Kenward MG;Wood AM;Carpenter JR
通讯作者：
Carpenter JR
影响因子：
6.2
作者：
Fucito LM;Czabafy S;Hendricks PS;Kotsen C;Richardson D;Toll BA;Association for the Treatment of Tobacco Use and Dependence/Society for Research on Nicotine and Tobacco Synergy Committee
通讯作者：
Association for the Treatment of Tobacco Use and Dependence/Society for Research on Nicotine and Tobacco Synergy Committee
影响因子：
1.9
作者：
PRENTICE, RL;KALBFLEISCH, JD;BRESLOW, NE
通讯作者：
BRESLOW, NE
影响因子：
168.9
作者：
Pirie, Kirstin;Peto, Richard;Beral, Valerie
通讯作者：
Beral, Valerie
早期肺癌诊断后戒烟对预后的影响：荟萃分析的观察性研究系统评价。
DOI：
10.1136/bmj.b5569
发表时间：
2010-01-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Parsons A;Daley A;Begh R;Aveyard P
通讯作者：
Aveyard P