Converging views of endocytosis in yeast and mammals
Converging views of endocytosis in yeast and mammals
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DOI：
10.1016/j.ceb.2010.05.009
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发表时间：
2010-08-01
影响因子：
7.5
通讯作者：
Conibear, Elizabeth
中科院分区：
文献类型：
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作者：
Conibear, Elizabeth
受体介导的内吞作用对于膜蛋白的选择性内化很重要。在哺乳动物中，网状蛋白、适配器和动力素在调节货物选择和囊泡形成方面发挥着重要作用。酵母的内吞作用通常是保守的，但在网状蛋白适配器、动力蛋白样蛋白和肌动蛋白的相对重要性上表现出显著而令人困惑的差异。最近的研究正在调和关于酵母和哺乳动物内吞过程的不同观点。哺乳动物细胞骨架蛋白适配器的酵母同系物的货物特异性功能的发现，迅速扩大了酵母中胞内适配器的数量。此外，已经提出了统一的模型来解释动力蛋白、肌动蛋白和膜变形蛋白如何驱动膜断裂。虽然仍然存在差异，但两个系统的发现将继续为对方提供信息。
Receptor-mediated endocytosis is important for the selective internalization of membrane proteins. In mammals, clathrin, adaptors, and dynamin play prominent roles in regulating cargo selection and vesicle formation. Endocytosis in yeast is generally conserved, but exhibits significant and perplexing differences in the relative importance of clathrin adaptors, dynamin-like proteins, and actin. Recent studies are now reconciling divergent views of endocytic processes in yeast and mammals. The discovery of cargo-specific functions for yeast homologs of mammalian clathrin adaptors has rapidly expanded the number of endocytic adaptors in yeast. Moreover, unifying models have been advanced to explain how dynamin, actin, and membrane-deforming proteins drive membrane scission. While differences remain, discoveries from each system will continue to inform the other.