HISTOLOGICAL FINE STRUCTURE OF PERINEURIUM
HISTOLOGICAL FINE STRUCTURE OF PERINEURIUM
复制标题
DOI：
10.1002/ar.1091580207
复制
发表时间：
1967-01-01
影响因子：
--
通讯作者：
BURKEL, WE
中科院分区：
文献类型：
--
作者：
BURKEL, WE
大鼠眼外肌有许多适合电镜研究的神经。小神经由1 ~ 10根有髓和无髓神经纤维组成，周围有2 ~ 3层神经束膜。神经束膜呈同心圆状排列，每一个细胞厚。连续的界膜将神经束膜与神经外膜和神经内膜组织空间分开，但界膜有时在单个神经束膜之间是斑点状的或不存在的。周围神经细胞的界膜的存在下区分他们从附近的成纤维细胞缺乏类似的膜投资。紧密的细胞间连接将构成每个袖的细胞连接起来，使得神经完全包被在神经束膜中。套管的数量随着神经变小而减少，无论是由最里面的套管的终止还是由套管的损失作为神经分支。最后一个套管在神经终止前不久结束。因此，神经束膜在外周是开放的，在这些地方，神经外膜和神经内膜是连续的。神经外膜和神经内膜之间的连续性也存在于供应神经的血管的入口和出口处以及网状纤维刺穿神经束膜的点处。这些结构特征与神经束膜作为扩散屏障和感染传播途径的作用密切相关。
Extraocular rat muscles possessed numerous nerves suitable for electron microscopic study. Small nerves composed of 1 to 10 myelinated and unmyelinated nerve fibers were surrounded by 2 or 3 layers of perineurium. The perineurium was arranged in concentric sleeves, each one cell thick. Continuous boundary membranes separated the perineural sleeves from the epineural and endoneural tissue space, but the boundary membranes were sometimes spotty or absent between individual sleeves. The presence of boundary membranes around perineural cells distinguished them from nearby fibroblasts which lacked similar membranous investment. Tight intercellular junctions joined the cells comprising each sleeve so that the nerves were completely ensheathed in perineurium. The number of sleeves decreased as the nerve became smaller, either by the termination of the innermost sleeve or by the loss of a sleeve as the nerve branched. The last sleeve ended shortly before the termination of the nerve. The perineurium was thus open-ended peripherally and, at these places, the epineurium and endoneurium were continuous. Continuities between the epineurium and endoneurium also existed at the entrance and exit to blood vessels supplying the nerve and at points where reticular fibers pierced the perineurium. These structural features correlated well with the action of the perineurium as a diffusion barrier and as a pathway in the transmission of infections.