Biochemical genetics of neurotransmitter enzymes and receptors: relationships to schizophrenia and other major psychiatric disorders.
Biochemical genetics of neurotransmitter enzymes and receptors: relationships to schizophrenia and other major psychiatric disorders.
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神经递质酶和受体的生化遗传学：与精神分裂症和其他主要精神疾病的关系。
DOI：
10.1111/j.1399-0004.1981.tb00727.x
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发表时间：
1981
影响因子：
3.5
通讯作者：
Boehme,RE
中科院分区：
文献类型：
--
作者：
Ciaranello,RD;Boehme,RE
Genetic control of catecholamine biosynthetic enzymes and dopamine receptors is described. The steady‐state levels of each of the catecholamine biosynthetic enzymes in the adrenal is regulated by a single genetic locus. The entire biosynthetic pathway gives the appearance of concerted inheritance under the control of a single locus. Mesolimbic and nigrostriatal dopamine receptors are also genetically regulated. Preliminary evidence suggests that agonist binding sites differ from antagonist sites in both brain regions, and that the genetic controls, which are expressed on receptor site number, are independent in the two brain regions.
