Stress-induced expression of transcriptional repressor ICER in the adrenal gland
Stress-induced expression of transcriptional repressor ICER in the adrenal gland
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DOI：
10.1016/s0014-5793(98)00944-2
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发表时间：
1998-08-28
期刊：
影响因子：
3.5
通讯作者：
Sassone-Corsi, P
中科院分区：
文献类型：
--
作者：
Della Fazia, MA;Servillo, G;Sassone-Corsi, P
第二信使环磷酸腺苷在下丘脑-垂体-肾上腺(HPA)轴的信号传递中起核心作用。基因表达的变化是肾上腺对压力做出长期适应的核心。在这里，我们证明了cAMP可诱导的转录抑制因子ICER(可诱导的cAMP早期抑制因子)的表达在大鼠肾上腺对手术应激的反应是快速而有力的。下丘脑切除可阻断应激诱导的ICER表达。最后，我们证明了注射垂体激素ACTH(促肾上腺皮质激素)可以诱导肾上腺皮质中ICER的表达。因此，转录抑制因子ICER的诱导与HPA轴对胁迫的反应有关。(C)1998年欧洲生化学会联合会。
Second messenger cyclic AMP plays a central role in signalling within the hypothalamo-pituitary-adrenal (HPA) axis. Changes in gene expression are central to long-term adaptations made in response to stress in the adrenal gland. Here we demonstrate that expression of the cAMP inducible transcriptional repressor, ICER (Inducible cAMP Early Repressor), is rapidly and powerfully induced in response to surgical stress in the rat adrenal gland. Hypophysectomisation blocks stress-induced ICER expression. Finally we demonstrate that injection of the pituitary hormone ACTH (Adrenocorticotropin Hormone) induces robust ICER expression in the adrenal cortex. Thus, induction of the transcriptional repressor ICER is coupled to the HPA axis response to stress. (C) 1998 Federation of European Biochemical Societies.