The high-affinity folate binding protein in normal and malignant mammary gland tissue.
The high-affinity folate binding protein in normal and malignant mammary gland tissue.
复制标题
正常和恶性乳腺组织中的高亲和力叶酸结合蛋白。
DOI：
10.1007/978-1-4615-2960-6_158
复制
发表时间：
1993
影响因子：
--
通讯作者：
M. Høier‐Madsen
中科院分区：
文献类型：
--
作者：
J. Holm;S. Hansen;K. Søndergaard;M. Høier‐Madsen
Human milk contains a soluble 25 kDa folate binding protein (FBP) as well as a membrane-derived FBP with a hydrophobic glycosyl-phosphatidylinositol tail; the enzyme phosphatidylinositol specific phospholipase C reduced the apparent size of the latter FBP from 100 to 25 kDa1. The two FBPs from human milk had identical N-terminal amino acid sequence for 39 cycles and shared antigenic determinants2,3. A high correlation between the concentrations of FBP and folate in milk suggested the secretion of a folate mammary FBP complex into milk4. In the present study we have characterized and compared FBP in the normal mammary gland and mammary tumors.
