Age-dependent modulation of in vivo cortical acetylcholine release by benzodiazepine receptor ligands.
Age-dependent modulation of in vivo cortical acetylcholine release by benzodiazepine receptor ligands.
复制标题
苯二氮卓受体配体对体内皮质乙酰胆碱释放的年龄依赖性调节。
DOI：
10.1016/0006-8993(92)91527-l
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发表时间：
1992
期刊：
影响因子：
2.9
通讯作者：
Bruno,JP
中科院分区：
文献类型：
--
作者：
Moore,H;Sarter,M;Bruno,JP
在体微透析法测定苯二氮受体(BZR)配体对清醒、年轻和老年大鼠皮质乙酰胆碱(ACh)释放的影响。基础皮质ACh释放量与年龄无显著差异。给予BZR选择性反向激动剂ZK 93 426可增加两组动物的ACh释放，但老年大鼠表现出更大的刺激作用。出乎意料的是，在目前的测试条件下，BZR激动剂氯氮卓酮(CDP)对两组ACh的释放都没有系统的影响。这些药物效应或药物年龄相互作用的存在或不存在并不次于这些化合物对行为活动的影响。大脑皮层ACh的释放也可以通过关闭观察室的灯或全身给予东莨菪碱来刺激。老年大鼠至少和年轻的大鼠一样能够对这些操作做出反应，释放更多的物质。这些结果表明，在所研究的年龄段，大脑皮层ACh的基础和刺激释放没有受到损害。此外，选择性反向BZR激动剂可能是跨突触刺激皮质胆碱能传递的有效途径。
In vivo microdialysis was utilized to determine the effects of benzodiazepine receptor (BZR) ligands on cortical acettylcholine (ACh) release in awake young and aged rats. There were no significant differences in baseline cortical ACh release as a function of age. While administration of the BZR selective inverse agonist ZK 93 426 increased ACh release in both groups of animals, the aged rats exhibited a greater stimulation. Unexpectedly, under the present testing conditions, the BZR agonist chlodiazepoxide (CDP) had no systematic effect on ACh release in either group. The presence or absence of these drug effects or drug-age interactions was not secondary to the impact of these compounds on behavioral activity. Cortical ACh release could also be stimulated by turning off the lights in the observation room or by the systemic administration of scopolamine. Aged rats were at least as able as their younger counterparts to respond to these manipulations with increased release. These results suggest that basal and stimulated release of cortical ACh is not impaired at the ages studied. Moreover, selective inverse BZR agonist may be a potent way of trans-synaptically stimulating cortical cholinergic transmission.