Non-invasive quantification of pancreatic exocrine function using secretin-stimulated MRCP
Non-invasive quantification of pancreatic exocrine function using secretin-stimulated MRCP
复制标题
使用促胰液素刺激的 MRCP 对胰腺外分泌功能进行无创定量
DOI：
10.1007/s00330-002-1605-x
复制
发表时间：
2003
影响因子：
5.9
通讯作者：
W. Lees
中科院分区：
文献类型：
--
作者：
S. Punwani;A. Gillams;W. Lees
抽象的。我们的目的是量化水的体积使用磁共振胰胆管造影（MRCP）序列，并将其应用于分泌素刺激的研究，目的是量化胰腺外分泌功能。使用市售的单次激发MRCP序列，结合体相阵列线圈和1.5 T MR系统。在水、胰液、十二指肠液和分泌素刺激的胰液样品中测量信号强度。制作了一个水模型，并将MR计算的体积与模型内的已知水量进行了比较。在一组11例无胰腺疾病证据的患者中测量了对促胰液素反应的小肠体积变化。绘制水体积随时间的变化。记录胰泌素注射前后胰管直径，寻找充盈缺损。所有患者还接受了轴向屏气T1加权梯度回波序列，并评估了胰腺实质的大小和信号强度。不同果汁样品的信号强度没有差异。已知MRCP体积与计算MRCP体积之间具有良好的相关性（χ 2 = 0.99）。所有患者在MRCP上显示正常的胰管形态，在T1加权成像上显示正常的胰腺实质。患者人群的平均流速为8.1 ± 2.5 ml/s，中位数为7 min（范围5 - 9 min）。MRCP序列可用于测量水量。连续MRCP测量后分泌素允许计算体积变化和流速。这应该证明是有用的胰腺外分泌功能的指标。
Abstract. Our objective was to quantify water volume using magnetic resonance cholangiopancreatography (MRCP) sequences and apply this to secretin-stimulated studies with the aim of quantifying pancreatic exocrine function. A commercially available single-shot MRCP sequence was used in conjunction with a body phased-array coil and a 1.5-T MR system. Signal intensity was measured in samples of water, pancreatic, duodenal juice, and secretin-stimulated pancreatic juice. A water phantom was made and MR calculated volumes compared with known water volumes within the phantom. Changes in small intestinal volume in response to secretin were measured in a group of 11 patients with no evidence of pancreatic disease. Changes in water volume were plotted over time. The pancreatic duct diameter before and after secretin was noted and filling defects were sought. All patients also underwent an axial breath-hold T1-weighted gradient-echo sequence and the pancreatic parenchyma was evaluated for size and signal intensity. There was no difference in the signal intensity of the different juice samples. There was excellent correlation between known and calculated MRCP volumes (χ2=0.99). All patients demonstrated normal duct morphology on MRCP and normal pancreatic parenchyma on T1-weighted imaging. The mean flow rate in the patient population was 8.1±2.5 ml/s over a median of 7 min (range 5–9 min). The MRCP sequence can be used to measure water volume. Sequential MRCP measurements following secretin permitted calculation of volume change and flow rate. This should prove useful as an indicator of pancreatic exocrine function.