Fabrication and histological evaluation of ant‐nest type porous carbonate apatite artificial bone using polyurethane foam as a porogen
Fabrication and histological evaluation of ant‐nest type porous carbonate apatite artificial bone using polyurethane foam as a porogen
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以聚氨酯泡沫为致孔剂的蚁巢型多孔碳酸盐磷灰石人工骨的制备及组织学评价
DOI：
10.1002/jbm.b.35173
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Ishikawa Kunio
中科院分区：
文献类型：
--
作者：
Tan Janice Lay Tin;Shimabukuro Masaya;Kishida Ryo;Ishikawa Kunio
碳酸磷灰石（CO3Ap）的组成有助于骨再生。其他特征，如人造骨的孔隙率和孔隙互连性，也控制骨再生。通常，人工骨的孔隙率和机械强度之间存在权衡。因此，这表明人工骨的蚂蚁窝型多孔（ANP）结构中的互连孔通过最大限度地减少机械强度的牺牲来加速骨再生。聚氨酯泡沫的独特结构具有赋予CO3Ap ANP结构而不形成过量孔的潜力。本研究探讨了聚氨酯泡沫作为致孔剂在为CO3Ap人工骨提供ANP结构方面的功效。聚氨酯泡沫通过烧结完全分解，并且所得的CO3Ap显示具有约15 MPa的压缩强度的ANP结构。此外，体内实验表明，细胞和组织通过互连孔迁移到CO3Ap内部，加速了ANP结构的CO3Ap中的骨再生。因此，这表明使用聚氨酯泡沫作为致孔剂赋予CO3Ap人工骨加速骨再生的ANP结构。
The composition of carbonate apatite (CO3Ap) aids bone regeneration. Other features, such as porosity and pore interconnectivity of artificial bone, also govern bone regeneration. In general, a trade‐off exists between the porosity and mechanical strength of artificial bone. Therefore, this suggests that the interconnected pores in the ant‐nest‐type porous (ANP) structure of artificial bone accelerate bone regeneration by minimizing the sacrifice of mechanical strength. The unique structure of polyurethane foam has the potential to endow CO3Ap with an ANP structure without forming excess pores. This study investigated the efficacy of polyurethane foam as a porogen in providing ANP structure to CO3Ap artificial bone. The polyurethane foam was completely decomposed by sintering and the resulting CO3Ap displayed ANP structure with a compressive strength of approximately 15 MPa. Furthermore, in vivo experiments revealed that the migration of cells and tissues into the interior of CO3Ap through the interconnected pores accelerated bone regeneration in the ANP‐structured CO3Ap. Thus, this indicates that using polyurethane foam as a porogen endows the CO3Ap artificial bone with an ANP structure that accelerates bone regeneration.