Diarylprolinol in an Asymmetric, Direct Cross-Aldol Reaction with Alkynyl Aldehydes
Diarylprolinol in an Asymmetric, Direct Cross-Aldol Reaction with Alkynyl Aldehydes
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DOI：
10.1002/cctc.201300390
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发表时间：
2013-10-01
期刊：
影响因子：
4.5
通讯作者：
Sato, Itaru
中科院分区：
文献类型：
--
作者：
Hayashi, Yujiro;Kojima, Masahiro;Sato, Itaru
三氟甲基化二芳基脯氨醇催化炔醛的直接交叉羟醛缩合反应为高对映选择性合成手性炔羟基醛提供了一条实用的路线。硅基丙炔醛的反应具有良好的反选择性和对映选择性，是合成有用的手性结构单元。
The direct cross-aldol reaction of alkynyl aldehydes catalyzed by a trifluoromethylated diarylprolinol provides a practical route for the highly enantioselective synthesis of chiral -alkynyl--hydroxy aldehydes. Good anti selectivity and excellent enantioselectivity were obtained in the reactions of silylpropynals, which afford synthetically useful chiral building blocks.