Symptoms and palliative care needs of pancreatic adenocarcinoma patients.
Symptoms and palliative care needs of pancreatic adenocarcinoma patients.
复制标题
胰腺腺癌患者的症状和姑息治疗需求。
DOI：
10.1089/jpm.2014.0056
复制
发表时间：
2014
影响因子：
2.8
通讯作者：
Palesh,Oxana
中科院分区：
文献类型：
--
作者：
Luo,Jia;Chen,JieJane;Deguzman,Carl;Mustian,Karen;Insco,Megan;Fisher,George;Palesh,Oxana
Dear Editor: Pancreatic adenocarcinoma is the fourth leading cause of cancer-related death in the United States with an overall five-year survival rate of 6%. 1 About 20% of pancreatic adenocarcinoma patients die within one year of diagnosis and those with metastatic disease at the time of diagnosis have a median survival of three to six months. 2, 3 Early supportive care has been shown to improve quality of life and increase survival in lung cancer patients. 4 Previous literature has described depression and gastrointestinal symptoms as common prodromes for pancreatic adenocarcinoma. One study found depression in 38% of pancreatic cancer patients surveyed. 5, 6 However, little is known about pancreatic cancer patients’ supportive care needs. 7 Given the short life expectancy of these patients, early supportive care may be essential in improving patient’s quality of life and possibly length of life.We designed an online survey to assess symptoms and symptom management of newly diagnosed patients with pancreatic cancer. The survey was developed using input by focus groups comprised of patients with pancreatic adenocarcinoma, their caregivers, and their medical providers. The survey included questions about symptoms before and after diagnosis, medications used for symptom management, and participation in psychological and mind-body interventions. Patients with pancreatic adenocarcinoma seen in an oncologist’s clinic at Stanford from November 2012 to September 2013 participated in the longitudinal study, including baseline and monthly follow-up surveys. Non-English speakers and patients transitioning to hospice were excluded. Of 25 patients approached, 22 (88%) consented to participate and 16 (73%) completed the baseline questionnaire. The mean age of participants was 66 (SD= 9.2; range= 44–80 years). There was an equal number of men and women and the majority of participants were Caucasian (75%). Seventy five percent of participants were status post tumor resection with 62.5% having received a Whipple procedure. The median time between participant diagnosis and completion of the baseline survey was 6.1 months (range= 0.8–29.3). In contrast to previous literature, we found that most participants in our sample did not experience either gastrointestinal symptoms or depression. Prior to a diagnosis of
