Limited impact of Delta variant’s mutations in the effectiveness of neutralization conferred by natural infection or COVID-19 vaccines in a Latino population.
Limited impact of Delta variant’s mutations in the effectiveness of neutralization conferred by natural infection or COVID-19 vaccines in a Latino population.
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Delta 变体突变对拉丁裔人群中自然感染或 COVID-19 疫苗的中和效果影响有限。
DOI：
10.1101/2021.10.25.21265422
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发表时间：
2021
期刊：
影响因子：
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通讯作者：
Espino,AnaM
中科院分区：
文献类型：
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作者：
Sariol,CarlosA;Serrano-Collazo,Crisanta;Ortiz,EdwinJ;Pantoja,Petraleigh;Cruz,Lorna;Arana,Teresa;Atehortua,Dianne;Pabon-Carrero,Christina;Espino,AnaM
SARS-CoV-2 大流行影响了世界各地的公共卫生系统。 Delta 变种似乎具有增强的传播性，但没有明确的证据表明它的毒力增强。我们的数据显示，预先暴露的个体对真实的 COVID-19 毒株以及 Delta 和 Epsilon 变种具有类似的中和活性。仅接种一剂疫苗后，中和能力就扩展到预先暴露于个体的所有测试变异。健康的接种疫苗的个体表现出有限的中和作用。一剂疫苗确实诱导了与真实菌株类似的针对 Delta 的中和抗体。然而，即使在两次给药后，这种能力也仅扩展到 Epsilon 变体。
The SARS-CoV-2 pandemic has impacted public health systems all over the world. The Delta variant seems to possess enhanced transmissibility, but no clear evidence suggests it has increased virulence. Our data show that pre-exposed individuals had similar neutralizing activity against the authentic COVID-19 strain and the Delta and Epsilon variants. After only one vaccine dose, the neutralization capacity expanded to all tested variants in pre-exposed individuals. Healthy vaccinated individuals showed a limited breadth of neutralization. One vaccine dose did induce similar neutralizing antibodies against the Delta as against the authentic strain. However, even after two doses, this capacity only expanded to the Epsilon variant.