Visceral adiposity as a risk factor for lean non-alcoholic fatty liver disease in potential living liver donors
Visceral adiposity as a risk factor for lean non-alcoholic fatty liver disease in potential living liver donors
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DOI：
10.1111/jgh.15597
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发表时间：
2021-07-03
影响因子：
4.1
通讯作者：
Lee, Sung-Gyu
中科院分区：
文献类型：
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作者：
Lee, Sunyoung;Kim, Kyoung Won;Lee, Sung-Gyu
背景和目的本研究旨在探讨活体瘦肝供体候选者中通过活检评估的肝脂肪变性（HS）与通过计算机断层扫描评估的内脏肥胖之间的关系，并确定瘦非酒精性脂肪性肝病（NAFLD）的危险因素。方法这项回顾性研究包括250名瘦型（体重指数，< 23 kg/m2）潜在的活体肝脏供体（平均年龄，31.1 ± 8.6岁; 141名男性），他们在2017年至2018年期间接受了肝活检和腹部计算机断层扫描。人体测量，实验室参数，身体成分，和HS的程度进行了评价。Logistic回归用于确定瘦型NAFLD的独立预测因子。结果男性（r = 0.408; P < 0.001）和女性（r = 0.360; P <0.001）的内脏脂肪面积（VFA）与HS程度呈显著相关。男性皮下脂肪面积与HS程度呈显著相关（r = 0.398; P < 0.001），而女性无相关性。骨骼肌面积与男性或女性的HS程度无关。在多因素Logistic回归分析中，VFA（比值比[OR]，1.028; 95%置信区间[CI]，1.013-1.044; P < 0.001）和皮下脂肪面积（OR，1.016; 95%CI，1.004-1.028; P = 0.009）是男性瘦型NAFLD的独立危险因素，而VFA（OR，1.036; 95%CI，1.013-1.059; P = 0.002）是女性瘦型NAFLD的独立危险因素。结论在偏瘦的亚洲人群中，非酒精性脂肪肝的严重程度与内脏脂肪堆积呈正相关。内脏肥胖可能是潜在活体肝脏供体中瘦型NAFLD的危险因素。
Background and Aim This study aimed to investigate the relationship between hepatic steatosis (HS) evaluated by biopsy and visceral adiposity assessed by computed tomography in lean living liver donor candidates and to determine the risk factors for lean non-alcoholic fatty liver disease (NAFLD). Methods This retrospective study included 250 lean (body mass index, < 23 kg/m(2)) potential living liver donors (mean age, 31.1 +/- 8.6 years; 141 men) who had undergone liver biopsy and abdominal computed tomography between 2017 and 2018. Anthropometry, laboratory parameters, body composition, and the degree of HS were evaluated. Logistic regression was used to identify independent predictors of lean NAFLD. Results The visceral fat area (VFA) was significantly correlated with the degree of HS in men (r = 0.408; P < 0.001) and women (r = 0.360; P < 0.001). The subcutaneous fat area was significantly correlated with the degree of HS in men (r = 0.398; P < 0.001), but not in women. The skeletal muscle area did not correlate with the degree of HS in either men or women. In the multivariable logistic regression analysis, the VFA (odds ratio [OR], 1.028; 95% confidence interval [CI], 1.013-1.044; P < 0.001) and subcutaneous fat area (OR, 1.016; 95% CI, 1.004-1.028; P = 0.009) were independent risk factors for lean NAFLD in men, and the VFA (OR, 1.036; 95% CI, 1.013-1.059; P = 0.002) was an independent risk factor for lean NAFLD in women. Conclusions The severity of non-alcoholic fatty liver was positively correlated with visceral fat accumulation in a lean Asian population. Visceral adiposity may be a risk factor for lean NAFLD in potential living liver donors.