Saliva interleukin‐17 levels are decreased in patients with severe oral candidiasis
Saliva interleukin‐17 levels are decreased in patients with severe oral candidiasis
复制标题
严重口腔念珠菌病患者唾液白细胞介素 17 水平降低
DOI：
10.1002/osi2.1178
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Yoshimasa Kitagawa
中科院分区：
文献类型：
--
作者：
Noritaka Ohga ; Ken‐ichiro Sakata ; Hiroyuki Hato ; Takuya Asaka ; Jun Sato ; Yoshimasa Kitagawa
目的口腔念珠菌病常合并其他口腔疾病，由于口腔念珠菌病常复发，因此长期随访至关重要。如果不对口腔念珠菌病提供适当的治疗，将导致真菌细胞在口腔中持续存在，并增加严重口腔念珠菌病和感染复发的风险。我们假设各种炎症细胞因子参与口腔念珠菌病的发病机制和进展。MethodsWe测量了念珠菌阴性和念珠菌阳性patients.ResultsSaliva IL-17浓度的唾液样本中的细胞因子水平，口腔念珠菌病患者的唾液中IL-17浓度显著低于健康人。念珠菌阳性患者的唾液IL-17 A浓度显著低于念珠菌阴性患者。结论口腔念珠菌病患者唾液中IL-17 A水平明显低于正常人，为口腔念珠菌病的发病机制和病情进展提供了一个潜在的高度有用的指标。
AimOral candidiasis is often complicated by other oral diseases, and long‐term follow‐up is essential because oral candidiasis often recurs. Failure to provide appropriate treatment for oral candidiasis will lead to persistence of the fungal cell in the oral cavity and increase the risk of severe oral candidiasis and recurrence of infection. We hypothesized that various inflammatory cytokines are involved in the pathogenesis and progression of oral candidiasis.MethodsWe measured cytokine levels in the saliva samples of candida‐negative and candida‐positive patients.ResultsSaliva interleukin (IL)‐17 concentrations were significantly lower in patients with oral candidiasis than in healthy individuals. Saliva IL‐17A concentrations were significantly lower in candida‐positive patients than in candida‐negative patients. However, the levels of tumor necrosis factor‐α, IL‐2, IL‐4, IL‐5, and IL‐6 showed no significant differences between the two groups of patients.ConclusionSaliva IL‐17A levels were significantly lower in patients with severe oral candidiasis, providing a potentially highly useful indicator for the pathogenesis and progression of severe oral candidiasis.
影响因子：
4.6
作者：
Sippl N;Faustini F;Rönnelid J;Turcinov S;Chemin K;Gunnarsson I;Malmström V
通讯作者：
Malmström V
消除口腔念珠菌病可能会增加受刺激的全唾液流量 Masahiro Morimoto
DOI：
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发表时间：
2016
期刊：
影响因子：
--
作者：
森本真弘;大賀則孝;佐藤 淳;浅香卓哉;秦 浩信 宮腰昌明;吉川和人;佐藤千晴;山崎 裕;北川善政
通讯作者：
北川善政
影响因子：
3.5
作者：
Hato, Hiroyuki;Sakata, Ken-ichiro;Sato, Jun;Hasebe, Akira;Yamazaki, Yutaka;Kitagawa, Yoshimasa
通讯作者：
Kitagawa, Yoshimasa