Injury induces presenilin-1 gene expression in mouse brain
Injury induces presenilin-1 gene expression in mouse brain
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DOI：
10.1097/00001756-199607290-00016
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发表时间：
1996-07-29
期刊：
影响因子：
1.7
通讯作者：
LaFerla, FM
中科院分区：
文献类型：
--
作者：
Cribbs, DH;Chen, LS;LaFerla, FM
有关影响早老素 -1（PS -1）表达的遗传因素和环境条件的信息，对于阐明其在阿尔茨海默病（AD）中的病理生理作用至关重要。先前的原位杂交研究表明，在生理条件下，神经元是哺乳动物中枢神经系统（CNS）中表达PS -1的主要细胞类型。在这项研究中，我们检测了实验诱导的局灶性损伤对小鼠中枢神经系统中PS -1基因表达的影响。对白质区域的物理损伤导致紧邻损伤部位的非神经元细胞中PS -1基因表达显著增加。这些发现强调了将头部损伤视为阿尔茨海默病风险因素的流行病学证据，并提示PS -1在这方面可能具有的作用。
INFORMATION regarding the genetic factors and environmental conditions that influence presenilin-1 (PS-1) expression is essential for the elucidation of its pathophysiological role in Alzheimer's disease (AD). Previous in situ hybridization studies have demonstrated that neurons are the predominant cell type expressing PS-1 in the mammalian central nervous system (CNS) under physiological conditions. In this study, we examined the consequences of an experimentally induced focal injury on PS-1 gene expression in the mouse CNS. Physical lesions to white matter regions produced a robust increase in PS-1 gene expression in non-neuronal cells immediately surrounding the site of injury. These findings underscore the epidemiological evidence that implicate head injury as a risk factor for AD and suggest a possible role for PS-1 in this capacity.