Endothelial-Mesenchymal Transition in Regenerative Medicine.
Endothelial-Mesenchymal Transition in Regenerative Medicine.
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DOI：
10.1155/2016/6962801
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发表时间：
2016
影响因子：
4.3
通讯作者：
Medici D
中科院分区：
文献类型：
--
作者：
Medici D
内皮-间充质转化（EndMT）是一种基本的细胞机制，它调控胚胎发育以及癌症和纤维化等疾病。生物医学研究的最新进展显示出利用EndMT过程进行组织工程和再生的巨大潜力。作为传统或人工干细胞疗法的一种替代方法，EndMT可能通过模拟自然发生的过程，代表了一种构建新组织以治疗退行性疾病的安全方法。这篇综述讨论了EndMT的信号传导机制和治疗性抑制剂，以及EndMT在发育、疾病、获得干细胞特性和生成结缔组织中的作用，及其作为组织再生新机制的潜力。
Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. This review discusses the signaling mechanisms and therapeutic inhibitors of EndMT, as well as the role of EndMT in development, disease, acquiring stem cell properties and generating connective tissues, and its potential as a novel mechanism for tissue regeneration.