Predictive Value of Eosinophil Count on COVID-19 Disease Progression and Outcomes, a Retrospective Study of Leishenshan Hospital in Wuhan, China.
Predictive Value of Eosinophil Count on COVID-19 Disease Progression and Outcomes, a Retrospective Study of Leishenshan Hospital in Wuhan, China.
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嗜酸性粒细胞计数对 COVID-19 疾病进展和结果的预测价值，中国武汉雷神山医院的回顾性研究
DOI：
10.1177/08850666211037326
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发表时间：
2022-03
影响因子：
3.1
通讯作者：
Su D
中科院分区：
文献类型：
--
作者：
Xuan W;Jiang X;Huang L;Pan S;Chen C;Zhang X;Zhu H;Zhang S;Yu W;Peng Z;Su D
背景嗜酸性粒细胞在COVID-19大流行中的潜在保护作用引起了人们的极大兴趣，因为它们具有潜在的病毒清除功能以及哮喘患者对这种冠状病毒的感染抵抗力。然而，目前尚不清楚嗜酸性粒细胞计数是否可以作为COVID-19严重程度的预测因子。方法选取武汉市雷神山医院收治的确诊COVID-19患者1004例，其中普通病房905例，重症监护病房（ICU）99例。我们回顾了他们的医疗资料，分析嗜酸性粒细胞与ICU入院和死亡之间的关系。结果在我们的1004例COVID-19患者中，在严重病例中观察到低嗜酸性粒细胞计数/比率。在调整可能影响结果的混杂因素后，我们发现嗜酸性粒细胞计数可能不是ICU入院的预测因子。在99名ICU患者中，其中58人存活，41人死亡，低嗜酸性粒细胞水平是重症COVID-19患者死亡的指标，临界值为0.04 × 109/L，曲线下面积为0.665（95%CI = 1.089-17.839; P = 0.045），敏感性和特异性分别为0.569和0.7317。结论低嗜酸性粒细胞水平是ICU患者死亡的预测因子，而不是ICU入院的原因。
Background The potential protective role of eosinophils in the COVID-19 pandemic has aroused great interest, given their potential virus clearance function and the infection resistance of asthma patients to this coronavirus. However, it is unknown whether eosinophil counts could serve as a predictor of the severity of COVID-19. Methods A total of 1004 patients with confirmed COVID-19 who were admitted to Leishenshan Hospital in Wuhan, China, were enrolled in this study, including 905 patients in the general ward and 99 patients in the intensive care unit (ICU). We reviewed their medical data to analyze the association between eosinophils and ICU admission and death. Results Of our 1004 patients with COVID-19, low eosinophil counts/ratios were observed in severe cases. After adjusting for confounders that could have affected the outcome, we found that eosinophil counts might not be a predictor of ICU admission. In 99 ICU patients, 58 of whom survived and 41 of whom died, low eosinophil level was an indicator of death in severe COVID-19 patients with a cutoff value of 0.04 × 109/L, which had an area under the curve of 0.665 (95% CI = 1.089-17.839; P = .045) with sensitivity and specificity of 0.569 and 0.7317, respectively. Conclusion Our research revealed that a low eosinophil level is a predictor of death in ICU patients rather than a cause of ICU admission.
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影响因子：
9.1
作者：
Liu S;Zhi Y;Ying S
通讯作者：
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影响因子：
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DOI：
10.1164/rccm.202003-0543oc
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影响因子：
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