DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker
DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker
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DOI：
10.1039/c1cc10222b
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发表时间：
2011-01-01
影响因子：
4.9
通讯作者：
Winssinger, Nicolas
中科院分区：
文献类型：
--
作者：
Gorska, Katarzyna;Manicardi, Alex;Winssinger, Nicolas
核酸模板反应在核酸传感领域引起了人们的广泛关注。在此，我们报告了一种通用设计，其扩展了核酸模板化反应的潜力，以释放多种多样的小分子的功能，例如转录因子激动剂、细胞毒性剂或荧光团。
Nucleic acid templated reactions have attracted significant attention for nucleic acid sensing. Herein we report a general design which extends the potential of nucleic acid templated reactions to unleash the function of a broad diversity of small molecules such as a transcription factor agonist, a cytotoxic or a fluorophore.