Attention-Guided Generative Adversarial Network to Address Atypical Anatomy in Synthetic CT Generation.

Attention-Guided Generative Adversarial Network to Address Atypical Anatomy in Synthetic CT Generation.
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DOI:
10.1109/iri49571.2020.00034
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发表时间:
2020-08
期刊:
2020 IEEE 21st International Conference on Information Reuse and Integration for Data Science : IRI 2020 : proceedings : virtual conference, 11-13 August 2020. IEEE International Conference on Information Reuse and Integration (21st : 2...
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通讯作者:
Glide-Hurst CK
Glide-Hurst CK
中科院分区:
其他
文献类型:
--
作者:
Emami H;Dong M;Glide-Hurst CK

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最近,在放射治疗中,对使用合成CT(SynCT)的仅MR治疗计划的兴趣迅速增长。然而,为包含非典型解剖的医学图像开发类解决方案仍然是一个主要限制。本文提出了一种新的空间注意力引导的生成性对抗网络模型,该模型使用T1加权MRI图像作为输入来生成准确的合成层析以处理非典型解剖结构。在15例脑癌患者上的实验结果表明,注意-GAN优于现有的SynCT模型,在整个头部、骨骼和空气区域,SynCT和CT-SIM的平均MAE分别为85.223±12.08、232.41±60.86和246.38±42.67Hounsfield单位。定性分析表明,注意-GAN具有利用空间聚焦区域更好地处理孤立点、复杂解剖区域或手术后区域的能力,从而为支持近实时的仅限MR的治疗规划提供了强大的潜力。
Recently, interest in MR-only treatment planning using synthetic CTs (synCTs) has grown rapidly in radiation therapy. However, developing class solutions for medical images that contain atypical anatomy remains a major limitation. In this paper, we propose a novel spatial attention-guided generative adversarial network (attention-GAN) model to generate accurate synCTs using T1-weighted MRI images as the input to address atypical anatomy. Experimental results on fifteen brain cancer patients show that attention-GAN outperformed existing synCT models and achieved an average MAE of 85.223±12.08, 232.41±60.86, 246.38±42.67 Hounsfield units between synCT and CT-SIM across the entire head, bone and air regions, respectively. Qualitative analysis shows that attention-GAN has the ability to use spatially focused areas to better handle outliers, areas with complex anatomy or post-surgical regions, and thus offer strong potential for supporting near real-time MR-only treatment planning.
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