Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish.
Hippo signaling determines the number of venous pole cells that originate from the anterior lateral plate mesoderm in zebrafish.
复制标题
河马信号传导确定源自斑马鱼前侧板中胚层的静脉极细胞的数量。
DOI：
10.7554/elife.29106
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发表时间：
2018-05-29
期刊：
影响因子：
7.7
通讯作者：
Mochizuki N
中科院分区：
文献类型：
--
作者：
Fukui H;Miyazaki T;Chow RW;Ishikawa H;Nakajima H;Vermot J;Mochizuki N
侧板中胚层细胞向心脏区细胞的分化是心脏组织发育和功能性心肌细胞发生的关键步骤。Hippo信号控制心肌细胞增殖，但Hippo信号在早期心脏发生中的作用仍不清楚。在这里，我们表明，海马信号调节心房细胞的数量，通过指定的前侧板中胚层（ALPM），这是纳入心管的静脉极，并最终进入心房的心脏内的细胞的发育潜力。我们证明，海马信号通过大的肿瘤抑制激酶1/2调节BMP信号和表达的手2，一个关键的转录因子，参与心房心肌细胞的分化。总的来说，这些结果表明，Hippo信号通过调节将填充心脏心房的ALPM细胞的数量和身份来定义静脉极心肌细胞的数量。
The differentiation of the lateral plate mesoderm cells into heart field cells constitutes a critical step in the development of cardiac tissue and the genesis of functional cardiomyocytes. Hippo signaling controls cardiomyocyte proliferation, but the role of Hippo signaling during early cardiogenesis remains unclear. Here, we show that Hippo signaling regulates atrial cell number by specifying the developmental potential of cells within the anterior lateral plate mesoderm (ALPM), which are incorporated into the venous pole of the heart tube and ultimately into the atrium of the heart. We demonstrate that Hippo signaling acts through large tumor suppressor kinase 1/2 to modulate BMP signaling and the expression of hand2, a key transcription factor that is involved in the differentiation of atrial cardiomyocytes. Collectively, these results demonstrate that Hippo signaling defines venous pole cardiomyocyte number by modulating both the number and the identity of the ALPM cells that will populate the atrium of the heart.