Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism
Blm10 Protein Promotes Proteasomal Substrate Turnover by an Active Gating Mechanism
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DOI：
10.1074/jbc.m111.300178
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发表时间：
2011-12-16
影响因子：
4.8
通讯作者：
Schmidt, Marion
中科院分区：
文献类型：
--
作者：
Dange, Thomas;Smith, David;Schmidt, Marion
工作背景：协会的蛋白酶体核心与活化剂调节proteasome activity.Results：Blm 10协会增加蛋白酶体活性肽和非结构化蛋白酶体底物tau-441。结论：Blm 10通过C端对接激活蛋白酶体，促进蛋白质底物和多肽的转换。意义：Blm 10参与蛋白酶体活性的调节。
Background: Association of the proteasome core with activators regulates proteasome activity.Results: Blm10 association increases proteasome activity toward peptides and the unstructured proteasome substrate tau-441. This process is mediated by the C terminus of Blm10.Conclusion: C-terminal docking-mediated proteasome activation by Blm10 facilitates the turnover of peptide and protein substrates.Significance: Blm10 contributes to the regulation of proteasome activity.