Defining Comparative Effectiveness Research The Importance of Getting It Right
Defining Comparative Effectiveness Research The Importance of Getting It Right
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DOI：
10.1097/mlr.0b013e3181da3709
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发表时间：
2010-06-01
期刊：
影响因子：
3
通讯作者：
Sox, Harold C.
中科院分区：
文献类型：
--
作者：
Sox, Harold C.
确定比较有效性研究(CER)是医学研究所CER初始优先事项委员会的首要任务。医学研究所委员会通过确定6个现有定义中的共同主题来处理定义CER的任务。定义如下：“比较有效性研究是产生和综合证据，比较预防、诊断、治疗和监测临床状况或改善护理提供的替代方法的益处和危害。CER的目的是帮助消费者、临床医生、购买者和政策制定者做出明智的决定，从而在个人和人群层面上改善卫生保健。“这个定义中的关键词是”证据的产生和综合“(这意味着包括原始研究和系统审查)，”替代方法“(意味着在日常实践中典型的研究人群中进行面对面的比较)，以及”做出明智的决定“(这意味着关注有助于在替代方案之间做出决定的数据)。定义CER要求我们决定我们希望从有关卫生保健的决策中获得什么。定义还具有官僚功能：它们可以设定界限，划定哪些研究有资格获得CER项目资金。定义--以及推动他们实现目标的资金--可以重塑研究环境。
Defining comparative effectiveness research (CER) was the first order of business for the Institute of Medicine Committee on Initial Priorities for CER. The Institute of Medicine committee approached the task of defining CER by identifying the common theme in the 6 extant definitions. The definition follows:"Comparative effectiveness research is the generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care. The purpose of CER is to assist consumers, clinicians, purchasers, and policy makers to make informed decisions that will improve health care at both the individual and population levels."The key words in this definition are "generation and synthesis of evidence" ( which implies both original research and systematic reviews), "alternative methods" ( which implies making head to head comparisons in study populations typical of daily practice), and "to make informed decisions" ( which implies a focus on data that helps to decide between alternatives).Defining CER requires us to decide what we want from decisions about health care. Definitions also serve a bureaucratic function: they can set boundaries that delineate which research is eligible for CER program funding. Definitions-and the funding that advances their goals-can reshape the research environment.