CD14+ follicular dendritic cells in lymphoid follicles may play a role in the pathogenesis of IgG4-related disease
CD14+ follicular dendritic cells in lymphoid follicles may play a role in the pathogenesis of IgG4-related disease
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DOI：
10.2220/biomedres.36.143
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发表时间：
2015-04-01
影响因子：
1.2
通讯作者：
Masaki, Yasufumi
中科院分区：
文献类型：
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作者：
Satoh-Nakamura, Tomomi;Kurose, Nozomu;Masaki, Yasufumi
增殖的IgG4(+)浆细胞是多克隆的，提示IgG4相关疾病(IgG4-RD)的发病机制涉及与IgG4扩张调节相关的上游事件。我们推测淋巴滤泡的形成可能在IgG4-RD的发病机制中起重要作用。使用各种抗体，特别是针对单核细胞、巨噬细胞和滤泡树突状细胞标志物的抗体，我们用免疫组织化学方法评估了免疫细胞在淋巴滤泡中的分布。对22例IgG4-RD、3例反应性增生、3例多中心性Castleman病和13例干燥综合征患者的组织标本进行病理分析。CD14阳性淋巴滤泡仅见于IgG4-RD患者，免疫组化证实CD14阳性细胞为滤泡树突状细胞。其他细胞类型在IgG4-RD组和对照组之间的分布差异不大。淋巴滤泡中CD14(+)滤泡树突状细胞的存在可能在IgG4-RD中起一定的病理生理作用。
Proliferated IgG4(+) plasma cells are polyclonal, suggesting that the pathogenesis of IgG4-related disease (IgG4-RD) involves upstream events related to the regulation of IgG4 expansion. We hypothesized that lymphoid follicle formation may play an important role in the pathogenesis of IgG4-RD. Using various antibodies, especially against monocyte, macrophage, and follicular dendritic cell markers, we immunohistochemically assessed the distribution of immune cells in lymphoid follicles. Pathological findings of tissue samples from patients with IgG4-RD (n = 22), reactive hyperplasia (n = 3), multicentric Castleman's disease (n = 3), and Sjogren's syndrome (n = 13) were analyzed. CD14-positive lymphoid follicles were observed only in patients with IgG4-RD, and CD14-positive cells were identified as follicular dendritic cells by multicolor immunohistochemistry. There were few differences in the distributions of other cell types between the IgG4-RD and control groups. The presence of CD14(+) follicular dendritic cells in lymphoid follicles may play a pathophysiological role in IgG4-RD.