ENDOTOXIN PROTECTION AGAINST OXYGEN-INDUCED ACUTE AND CHRONIC LUNG INJURY
ENDOTOXIN PROTECTION AGAINST OXYGEN-INDUCED ACUTE AND CHRONIC LUNG INJURY
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DOI：
10.1152/jappl.1979.47.3.577
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发表时间：
1979-01-01
影响因子：
3.3
通讯作者：
ROBERTS, RJ
中科院分区：
文献类型：
--
作者：
FRANK, L;ROBERTS, RJ
小剂量的内毒素（100-500 μ g/kg）[来自大肠杆菌、鼠伤寒沙门氏菌、沙门氏菌]。伤寒、福氏志贺菌和假单胞菌]提供显著的保护，防止肺O2毒性和致死性的急性表现。在内毒素处理的成年大鼠中，97%的大鼠在暴露于≥ 100 μ g/ml的条件下存活72小时。95%O2，肺部变化最小，而对照组动物为32%（P < 0.01）。暴露≥95%O2持续7天，未处理对照组大鼠的存活率为20%，内毒素处理组大鼠的存活率为98%（P < 0.01）。存活动物肺的组织学评价显示，内毒素处理的动物肺中胶原和网状纤维沉积显著减少。内毒素处理与肺的保护性抗氧化酶系统的活性增加相关，呈明显的剂量-反应方式。内毒素对O2毒性的保护活性似乎不依赖于对肺的初始毒性损伤，如α-内毒素。萘硫脲、油酸或四氧嘧啶处理。这些数据支持内毒素对O2诱导的肺损伤的急性和慢性表现的保护作用。
Small dosages of endotoxin (100-500 .mu.g/kg) [from Escherichia coli, Salmonella typhimurium, S. typhi, Shigella flexneri and Pseudomonas sp.] provide significant protection against the acute manifestations of pulmonary O2 toxicity and lethality. Of endotoxin-treated adult rats, 97% survived a 72 h exposure to .gtoreq. 95% O2 with minimal lung changes compared to 32% of control animals (P < 0.01). Exposure of .gtoreq. 95% O2 for 7 days resulted in a 20% survival rate in untreated control rats vs. 98% survival in endotoxin-treated rats (P < 0.01). Histological evaluation of lung from survivors revealed substantially less collagen and reticular fiber deposition in the endotoxin-treated animal lungs. Endotoxin treatment was associated with increased activity of the protectant antioxidant enzyme systems of the lung in an apparent dose-response manner. Endotoxin''s protective activity against O2 toxicity does not appear to depend on an initial toxic insult to the lung like with .alpha.-naphthylthiourea, oleic acid or alloxan treatment. The data support a protective role for endotoxin against the acute and the more chronic manifestations of O2-induced pulmonary injury.