Personal benefit, or benefiting others? Deciding whether to take part in clinical trials
Personal benefit, or benefiting others? Deciding whether to take part in clinical trials
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DOI：
10.1177/1740774510392257
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发表时间：
2011-02-01
期刊：
影响因子：
2.7
通讯作者：
Smith, Lorraine
中科院分区：
文献类型：
--
作者：
Locock, Louise;Smith, Lorraine
背景参与临床试验是循证医疗成功的关键。以往的许多研究表明，人们参与临床试验主要是出于利他的原因，而获取个人利益是次要的考虑因素。目的调查患者决定是否参加临床试验的原因以及个人利益可能成为激励因素的程度。方法采用深度半结构化访谈进行定性研究。参与者是42名男性和女性，他们被要求参加在不同条件下测试一系列干预措施的临床试验，其中包括一些没有参与或退出的人。试验以初级或二级保健为基础。访谈在家中进行。结果参加调查的原因复杂，个人考虑因素也很多。在这组受访者中，获得一些个人利益似乎是一个重要的主要动机，而利他主义似乎在很大程度上是次要的。决定不参与的人也主要关心个人风险和利益的平衡。限制公开传播结果可能影响了参与者的反应。结论通过了解可能激励患者参与的因素，可以提高临床试验的目标样本量。在这项研究中，受访者确定了一系列有吸引力的好处，例如由专家组成的专家团队的护理、积极参与他们的健康监测或护理、更频繁或更密集的监测，以及关于他们病情的最新研究的信息。临床试验2011；8：85-93。Http://ctj.sagepub.com.
Background Participation in clinical trials is critical for the success of evidence-based healthcare. Much previous research suggests that people take part in clinical trials mostly for altruistic reasons, and that deriving personal benefit is a secondary consideration.Purpose To investigate patients' reasons for deciding whether to take part in clinical trials and the extent to which personal benefit may be a motivating factor.Methods A qualitative study utilizing in-depth semi-structured interviews. Participants were 42 men and women who had been asked to participate in clinical trials testing a range of interventions in different conditions, including some who did not participate or withdrew. Trials were based in either primary or secondary care. Interviews were conducted at home.Results Reasons for taking part were complex and a wide variety of personal considerations were evident. Gaining some personal benefit emerged as an important primary motivation in this group of respondents, whereas altruistic considerations appeared to be largely subsidiary. People who decided not to take part were also mainly concerned about the balance of personal risk and benefit.Limitations Public dissemination of the results may have influenced participants' responses.Conclusions Achieving target sample sizes for clinical trials may be enhanced by an understanding of what is likely to motivate patients to take part. In this study, respondents identified a range of attractive benefits, such as care in a specialist team with expert staff, active engagement in their health monitoring or care, more frequent or intensive monitoring, and information about the latest research into their condition. Clinical Trials 2011; 8: 85-93. http://ctj.sagepub.com.