HIV virological non-suppression is highly prevalent among 18- to 24-year-old youths on antiretroviral therapy at the Kenyan coast.
HIV virological non-suppression is highly prevalent among 18- to 24-year-old youths on antiretroviral therapy at the Kenyan coast.
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在肯尼亚海岸的抗逆转录病毒疗法中，在18至24岁的年轻人中，HIV病毒学非抑制非常普遍。
DOI：
10.1186/s12879-022-07428-w
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发表时间：
2022-05-11
影响因子：
3.7
通讯作者：
Abubakar, Amina
中科院分区：
文献类型：
--
作者：
Nyongesa, Moses K.;Mwatasa, Mwaganyuma H.;Kagonya, Vincent A.;Mwambingu, Gabriel;Ngetsa, Caroline;Newton, Charles R. J. C.;Abubakar, Amina
关键词：
在撒哈拉以南非洲，参加抗逆转录病毒疗法(ART)的青年艾滋病毒携带者(YLWH)的病毒学结果数据仍然很少。在这项研究中，我们描述了肯尼亚沿海18-24岁青年妇女中艾滋病毒病毒学非抑制(VNS)的流行率及其相关因素。对384名青少年儿童的数据进行了分析，他们参与了2018年11月至2019年9月在肯尼亚沿海两个县(基利菲和蒙巴萨)进行的一项更大规模的横断面研究。描述性统计用于总结样本特征，Logistic回归用于与VNS相关的因素的统计建模。在本研究中，VNS被定义为血浆病毒载量 ≥ 1000拷贝/毫升。在这些平均年龄为20.7岁(SD = 2.2)的青壮年人群中，55.5%的女性总体患病率为32.0%(95%可信区间(95%CI)：27.5，36.9%)。在多因素Logistic回归分析中，来自农村的人群(调整后的优势比为1.73，95%CI为1.10，2.71；p = 为0.02)、体重不足(调整后的优势比为1.87，95%CI为1.16、3.01；p = 为0.01)和低自我报告的ART依从性(调整后的优势比为2.83，95%CI为1.34、6.00；p = 为0.01)与青少年儿童发生神经营养不良的风险显著相关。在这项研究中，青少年儿童中观察到了高水平的VNS，这与农村居民的居住、营养和ART坚持问题显著相关。在这种情况下，应加强对主要居住在农村地区的青少年儿童的抗逆转录病毒治疗、咨询、营养支持和教育。鉴于VNS的高频率，有必要密切监测病毒载量，并分析来自肯尼亚沿海确诊病毒学失败的年轻人的艾滋病毒耐药性模式。后者将有助于理解耐药性是否也是除了次优的ART依从性之外或排除在次优ART依从性之外的较差的病毒抑制。
In sub-Saharan Africa, data on virologic outcomes of young people living with HIV (YLWH) enrolled on antiretroviral therapy (ART) remains scarce. In this study, we describe the prevalence of HIV virological non-suppression (VNS) and its associated factors among YLWH aged 18–24 years from the Kenyan coast. Data were analyzed for 384 YLWH who participated in a larger cross-sectional study conducted between November 2018 and September 2019 in two counties at the Kenyan coast (Kilifi and Mombasa). Descriptive statistics were used to summarize sample characteristics and logistic regression was used for statistical modeling of factors associated with VNS. In this study, VNS was defined as plasma viral load ≥ 1000 copies/mL. Among these YLWH with a mean age of 20.7 years (SD = 2.2); 55.5% females, the overall prevalence of VNS was 32.0% (95% Confidence interval (95% CI): 27.5, 36.9%). In the multivariable logistic regression analysis, being from a largely rural setting (adjusted Odds Ratio (aOR) 1.73, 95% CI 1.10, 2.71; p = 0.02), underweight (aOR 1.87, 95% CI 1.16, 3.01; p = 0.01) and low self-reported ART adherence (aOR 2.83, 95% CI 1.34, 6.00; p = 0.01) were significantly associated with higher odds of VNS in YLWH. In this study, high levels of VNS were observed among YLWH and this was significantly associated with rural residency, nutritional and ART adherence problems. ART adherence counselling and nutritional support and education should be intensified in this setting targeting YLWH residing mostly in rural areas. Given the high frequency of VNS, there is need to closely monitor viral load and profile HIV drug resistance patterns in youths from the Kenyan coast with confirmed virologic failure. The latter will help understand whether drug resistance also contributes to poor viral suppression in addition to, or exclusive of suboptimal ART adherence.
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DOI：
10.1097/qad.0000000000000697
发表时间：
2015-06-19
期刊：
AIDS (London, England)
影响因子：
--
作者：
Kacanek D;Angelidou K;Williams PL;Chernoff M;Gadow KD;Nachman S;International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1055 Study Team
通讯作者：
International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1055 Study Team
DOI：
10.1097/qai.0000000000001670
发表时间：
2018-07-01
期刊：
Journal of acquired immune deficiency syndromes (1999)
影响因子：
--
作者：
Ahonkhai AA;Banigbe B;Adeola J;Bassett IV;Idigbe I;Okonkwo P;Freedberg KA;Regan S;Losina E
通讯作者：
Losina E
影响因子：
1
作者：
Getnet Demsie, Desalegn;Tilahun Bantie, Abere;Gebrie, Desye
通讯作者：
Gebrie, Desye
影响因子：
6
作者：
Kim MH;Mazenga AC;Yu X;Ahmed S;Paul ME;Kazembe PN;Abrams EJ
通讯作者：
Abrams EJ
影响因子：
1.4
作者：
Dworkin, Mark S.;Douglas, G. W.;Chakraborty, Apurba
通讯作者：
Chakraborty, Apurba