Sickle red cell-endothelium interactions.
Sickle red cell-endothelium interactions.
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DOI：
10.1080/10739680802279394
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Barabino GA
中科院分区：
文献类型：
--
作者：
Kaul DK;Finnegan E;Barabino GA
疼痛性血管闭塞危象的周期性复发是镰状细胞病的决定性特征。在与该疾病相关的多种病理中，镰状红细胞-内皮相互作用被认为是血管闭塞事件的潜在启动机制。本文综述了镰状红细胞粘附的各种相关机制。我们讨论镰状红细胞粘附的体外和微循环研究结果，其在血管闭塞中的潜在作用，以及目前对这种病理现象中涉及的受体-配体相互作用的理解。此外，我们还讨论了在转基因镰状小鼠模型中观察到的其他细胞相互作用（白细胞募集和白细胞-红细胞相互作用）对血管闭塞的贡献。重点是最近发现的粘附分子在介导人镰状红细胞粘附中起主导作用。最后，我们分析了通过靶向粘附分子抑制镰状红细胞粘附的各种治疗方法，并考虑了针对内皮细胞激活和粘附起始刺激的治疗策略。
Periodic recurrence of painful vaso-occlusive crisis is the defining feature of sickle cell disease. Among multiple pathologies associated with this disease, sickle-red cell-endothelium interaction has been implicated as potential initiating mechanism in vaso-occlusive events. This review focuses on various interrelated mechanisms involved in human sickle red cell adhesion. We discuss in vitro and microcirculatory findings on sickle red cell adhesion, its potential role in vaso-occlusion, and the current understanding of receptor-ligand interactions involved in this pathological phenomenon. In addition, we discuss the contribution of other cellular interactions (leukocytes recruitment and leukocyte-red cell interaction) to vaso-occlusion as observed in transgenic sickle mouse models. Emphasis is given to recently discovered adhesion molecules that play a predominant role in mediating human sickle red cell adhesion. Finally, we analyze various therapeutic approaches for inhibiting sickle red cell adhesion by targeting adhesion molecules, and also consider therapeutic strategies that target stimuli involved in endothelial activation and initiation of adhesion.
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