Macaque monkey retrosplenial cortex: III. Cortical efferents
Macaque monkey retrosplenial cortex: III. Cortical efferents
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DOI：
10.1002/cne.21346
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发表时间：
2007-06-10
影响因子：
2.5
通讯作者：
Amaral, David G.
中科院分区：
文献类型：
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作者：
Kobayashi, Yasushi;Amaral, David G.
我们用H-3-氨基酸作为顺行示踪剂研究了猕猴压后和后扣带回皮质的皮质传出投射。所有的注射都产生了与该地区其他地区的广泛的本地联系。也有一些外在传出皮质连接，其中许多迄今尚未报道。来自压后皮质的主要投射指向额叶，最重的终止于46、9、10和11区。也有非常大量的预测，内嗅皮层，前下托，和海马结构的旁下托，以及到海马旁皮层的TH和TF区。一些注射导致标记的区域V4，背侧银行的上级颞沟，和区域7a顶叶皮质。从后扣带回皮质的投射支配所有这些相同的区域，虽然终止的密度是不同的压后投射。后扣带回皮质产生了额外的投影顶叶区DP和皮质沿着凸的上级颞回。后扣带回腹侧部分（23 v区）比背侧部分（23 e和i区）向海马结构发出更密集的传出投射。这些连接进行了讨论有关的临床综合征的压后遗忘症和地形定向障碍，在人类中通常引起的尾腹侧部分的压后和后扣带皮层的病变。
We have investigated the cortical efferent projections of the macaque monkey retrosplenial and posterior cingulate cortices by using H-3-amino acids as anterograde tracers. All the injections produced extensive local connections to other portions of this region. There were also a number of extrinsic efferent cortical connections, many of which have not hitherto been reported. Major projections from the retrosplenial cortex were directed to the frontal lobe, with heaviest terminations in areas 46, 9, 10, and 11. There were also very substantial projections to the entorhinal cortex, presubiculum, and parasubiculum of the hippocampal formation, as well as to areas TH and TF of the parahippocampal cortex. Some injections led to labeling of area V4, the dorsal bank of the superior temporal sulcus, and area 7a of the parietal cortex. Projections from the posterior cingulate cortex innervated all these same regions, although the density of termination was different from the retrosplenial projections. The posterior cingulate cortex gave rise to additional projections to parietal area DP and to the cortex along the convexity of the superior temporal gyrus. The ventral portion of the posterior cingulate cortex (area 23v) gave rise to much denser efferent projections to the hippocampal formation than the dorsal portions (areas 23e and i). These connections are discussed in relation to the clinical syndromes of retrosplenial amnesia and topographic disorientation in humans commonly caused by lesions in the caudoventral portions of the retrosplenial and posterior cingulate cortices.