TRYPANOSOMA-CRUZI - ULTRASTRUCTURAL AND METABOLIC ALTERATIONS OF EPIMASTIGOTES BY BETA-LAPACHONE
TRYPANOSOMA-CRUZI - ULTRASTRUCTURAL AND METABOLIC ALTERATIONS OF EPIMASTIGOTES BY BETA-LAPACHONE
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DOI：
10.1016/0014-4894(77)90071-6
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发表时间：
1977-01-01
影响因子：
2.1
通讯作者：
SOUZA, WD
中科院分区：
文献类型：
--
作者：
DOCAMPO, R;LOPES, JN;SOUZA, WD
β-拉帕酮（一种 1,2-萘醌衍生物）引起克氏锥虫上鞭毛体的超微结构和代谢改变。在β-拉帕雄处理的细胞中，染色质排列成斑块，明显不同于染色质分布的正常模式。观察到核膜、线粒体膜和细胞质膜的改变以及线粒体的肿胀。与超微结构改变相伴的是呼吸频率的降低以及葡萄糖和丙酮酸氧化的抑制。
.beta.-Lapachone (a 1,2-naphthoquinone derivative) causes ultrastructural and metabolic alterations in T. cruzi epimastigotes. In .beta.-lapachone-treated cells the chromatin is arranged in patches, clearly differing from the normal pattern of chromatin distribution. Alterations of the nuclear, mitochondrial and cytoplasmic membranes as well as swelling of the mitochondrion are observed. Concomitant with the ultrastructural alterations is a reduction in the respiratory rate and inhibition of glucose and pyruvate oxidation.