Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy
Tricaprin Rescues Myocardial Abnormality in a Mouse Model of Triglyceride Deposit Cardiomyovasculopathy
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DOI：
10.5650/jos.ess18037
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发表时间：
2018-08-01
影响因子：
1.5
通讯作者：
Hirano, Ken-ichi
中科院分区：
文献类型：
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作者：
Suzuki, Akira;Yamaguchi, Satoshi;Hirano, Ken-ichi
甘油三酯存款心肌血管病（TGCV）是一种顽固性心血管疾病，迫切需要特异性治疗。在TGCV中，脂肪甘油三酯脂肪酶（ATGL）缺乏导致细胞内长链脂肪酸（LCFA）代谢异常，从而导致TG沉积。中链甘油三酯已被用作治疗多种人类疾病的重要功能性食品。为了解决中链甘油三酯tricaprin对TGCV心脏功能障碍的潜在活性，我们检查了tricaprin饮食对Atgl敲除（KO）小鼠（TGCV的动物模型）的影响。心脏成像测试显示，与饲喂对照饮食的小鼠相比，三癸酸甘油酯饮食减少了TG积累，这是由于LCFA代谢的改善，并且改善了Atgl KO小鼠的左心室功能。总之，三癸酸甘油酯改善了TGCV模型中的心肌异常，因此，它可能对TGCV患者的治疗有用。
Triglyceride deposit cardiomyovasculopathy (TGCV) is an intractable cardiovascular disease for which a specific treatment is urgently required. In TGCV, adipose triglyceride lipase (ATGL) deficiency results in the abnormal intracellular metabolism of long-chain fatty acid (LCFA) which leads to TG deposition. Medium-chain triglycerides have been used as an important functional food for various human diseases. To address the potential activities of tricaprin, a medium-chain triglyceride, on cardiac dysfunctions of TGCV, we examined the effects of tricaprin diet on Atgl knock out (KO) mice, an animal model for TGCV. Cardiac imaging tests showed that the tricaprin diet reduced TG accumulation, resulting from improvement of LCFA metabolism, and improved left ventricular function in Atgl KO mice compared to that in mice fed the control diet. In conclusion, tricaprin improved myocardial abnormality in the TGCV model, thus, it may be useful for the treatment of patients with TGCV.