Sexually dimorphic recruitment of dopamine neurons into the stress response circuitry.
Sexually dimorphic recruitment of dopamine neurons into the stress response circuitry.
复制标题
多巴胺神经元的性别二态性招募到应激反应回路中。
DOI：
10.1037/a0033807
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发表时间：
2013
影响因子：
1.9
通讯作者：
Neckameyer,WendiS
中科院分区：
文献类型：
--
作者：
Argue,KathrynJ;Neckameyer,WendiS
先前在哺乳动物系统中的几项研究已经显示了性二态行为，神经内分泌变化和神经递质释放的变化，以应对压力。此外，男性和女性对与压力有关的疾病的易感性不同，这导致了一种假设，即压力反应回路因性别而异。作者利用果蝇的遗传可塑性来操纵转基因动物的突触前或突触后多巴胺信号传导，这些转基因动物在暴露于2种环境应激因素（饥饿和氧化应激）后测定了运动和心率的几个参数。他们的研究结果显示，通过分析心率、居中时间和高流动性以及其他具有平移相关性的运动参数，男性和女性的应激反应存在显着差异。这些数据表明，前和突触后神经元差异招募到多巴胺能应激反应电路的男性和女性。结果还表明，反应电路不同的压力源和行为输出。此外，作者的研究提供了一个可翻译的果蝇模型，进一步阐明了参与神经元性二态招募进入应激反应回路的因素。（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
Several previous studies in mammalian systems have shown sexually dimorphic behaviors, neuroendocrine changes, and alterations in neurotransmitter release in response to stress. In addition, men and women are differentially vulnerable to stress-related pathologies, which have led to the hypothesis that the stress response circuitry differs depending on sex. The authors used the genetic tractability of Drosophila to manipulate pre-or postsynaptic dopamine signaling in transgenic animals, which were assayed for several parameters of locomotion and heart rate following exposure to 2 environmental stressors: starvation and oxidative stress. Their results show significant differences in the stress response for males and females by analyzing heart rate, centering time, and high mobility in addition to other locomotor parameters with translational relevance. These data demonstrate that both pre-and postsynaptic neurons are differentially recruited into the dopaminergic stress response circuitry for males and females. The results also show that the response circuits differ depending on the stressor and behavioral output. Furthermore, the authors’ studies provide a translatable Drosophila model for further elucidation of factors involved in the sexually dimorphic recruitment of neurons into the stress response circuitry.(PsycINFO Database Record (c) 2016 APA, all rights reserved)