Grid-like Processing of Imagined Navigation.
Grid-like Processing of Imagined Navigation.
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想象中的导航的网格状处理。
DOI：
10.1016/j.cub.2016.01.042
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发表时间：
2016-03-21
期刊：
影响因子：
--
通讯作者：
Burgess N
中科院分区：
文献类型：
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作者：
Horner AJ;Bisby JA;Zotow E;Bush D;Burgess N
啮齿类动物和人类内嗅觉皮质(EC)中的网格细胞以六角分布的空间周期性方式放电。与内侧颞叶(MTL)中的其他空间细胞协调，它们提供了我们在环境中的位置的表示，并被特别认为允许所表示的位置通过自我运动来更新。在整个自传体记忆系统中都可以看到网格状的信号，这表明在记忆中扮演着更普遍的角色。网格单元可能允许我们在想象中移动我们的观点，这对于目标导向的导航和规划是一个有用的功能，更广泛地说，是对未来的插曲思考。我们使用功能磁共振成像来提供证据，证明在虚拟导航和想象导航相同路径的过程中，人类内嗅皮层中存在类似的栅格状信号。我们发现，这一信号存在于活跃的导航和想象阶段，两者具有相似的取向，并具有格子细胞放电的特殊6倍旋转对称特征。因此，我们提供了第一个证据，表明网格细胞在图像中的视点移动过程中被利用，潜在地支持我们在精神上更普遍地穿越可能的路线的能力，以服务于规划和插曲的未来思维。随着哺乳动物主动地在环境中导航，网格细胞以一种空间模式发射网格细胞可能会移动想象力的视点，帮助目标导向导航人类内嗅觉皮质在想象的导航过程中显示出网格状的fMRI信号，该信号类似于霍纳等人在虚拟导航时在同一人身上看到的信号。当参与者想象在太空中导航时，在人类内嗅觉皮质中发现一个网格状的fMRI信号，类似于在虚拟现实中导航时看到的信号。因此，网格单元可以移动想象的视点，扩展它们在导航过程中更新自身位置的建议角色，以包括动态图像和规划。
Grid cells in the entorhinal cortex (EC) of rodents and humans fire in a hexagonally distributed spatially periodic manner. In concert with other spatial cells in the medial temporal lobe (MTL), they provide a representation of our location within an environment and are specifically thought to allow the represented location to be updated by self-motion. Grid-like signals have been seen throughout the autobiographical memory system, suggesting a much more general role in memory. Grid cells may allow us to move our viewpoint in imagination, a useful function for goal-directed navigation and planning, and episodic future thinking more generally. We used fMRI to provide evidence for similar grid-like signals in human entorhinal cortex during both virtual navigation and imagined navigation of the same paths. We show that this signal is present in periods of active navigation and imagination, with a similar orientation in both and with the specifically 6-fold rotational symmetry characteristic of grid cell firing. We therefore provide the first evidence suggesting that grid cells are utilized during movement of viewpoint within imagery, potentially underpinning our more general ability to mentally traverse possible routes in the service of planning and episodic future thinking. Grid cells fire in a spatial pattern as mammals actively navigate their environment Grid cells might move the viewpoint of imagination, aiding goal-directed navigation Human entorhinal cortex shows a grid-like fMRI signal during imagined navigation This signal is similar to that seen in the same people during virtual navigation Horner et al. find a grid-like fMRI signal in human entorhinal cortex as participants imagine navigating through space, similar to that seen during navigation in virtual reality. Thus, grid cells may move the viewpoint of imagination, extending their suggested role in updating self-location during navigation to include dynamic imagery and planning.