Effect of Fenthion on the Level of Vitellogenin in Goldfish, Carassius auratus
Effect of Fenthion on the Level of Vitellogenin in Goldfish, Carassius auratus
复制标题
倍硫磷对金鱼卵黄蛋白原水平的影响
DOI：
10.1248/jhs.45.262
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
A. Hara
中科院分区：
文献类型：
--
作者：
S. Kitamura;Mayumi Yoshida;K. Sugihara;S. Ohta;A. Hara
从诱导鱼类雌激素生物标志物卵黄蛋白原的角度，研究了杀虫剂倍硫磷对金鱼（Carassius auratus）的雌激素效应。雄性金鱼在含己烯雌酚（0.1mg/l）或壬基酚（0.5mg/l）的水中饲养5天后，血液中的卵黄原蛋白水平显著升高。然而，在含有倍硫磷（3毫克/升）的水中饲养5天的雄性金鱼血液中未检测到卵黄蛋白原。当雌性金鱼在含有倍硫磷的水中饲养5天时，血液中的卵黄蛋白原水平没有增加。此外，倍硫磷的氧化产物倍硫磷亚砜和倍硫磷砜在雄性金鱼中不诱导卵黄蛋白原。这些结果表明，倍硫磷及其氧化产物不会对金鱼产生雌激素活性。
The estrogenic effect of fenthion, an insecticide, in goldfish (Carassius auratus) was examined in terms of the induction of vitellogenin, a biomarker of estrogens in fish. When male goldfish were kept in water containing diethylstilbestrol (0.1mg/l) or nonylphenol (0.5mg/l) for 5 days, a significant level of vitellogenin in the blood was observed. However, vitellogenin was not detected in the blood of male goldfish kept in water containing fenthion (3mg/l) for 5 days. When female goldfish were kept in water containing fenthion for 5 days, the levels of vitellogenin in the blood were not enhanced . Furthermore, fenthion sulfoxide and fenthion sulfone, the oxidized products of fenthion, did not induce vitellogenin in male goldfish. These results suggest that fenthion and its oxidized products do not produce estrogenic activity in goldfish.