Protter: interactive protein feature visualization and integration with experimental proteomic data
Protter: interactive protein feature visualization and integration with experimental proteomic data
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DOI：
10.1093/bioinformatics/btt607
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发表时间：
2014-03-15
期刊：
影响因子：
5.8
通讯作者：
Wollscheid, Bernd
中科院分区：
文献类型：
--
作者：
Omasits, Ulrich;Ahrens, Christian H.;Wollscheid, Bernd
在丰富的蛋白质特征注释的背景下整合和可视化实验蛋白质组学证据的能力代表了蛋白质组学社区未满足的需求。在这里，我们提出了Protter，一个基于网络的工具，支持交互式蛋白质数据分析和假设生成的可视化注释的序列特征和实验蛋白质组数据的蛋白质拓扑结构的背景下。Protter支持多种蛋白质组文件格式，并自动集成了各种参考蛋白质注释源，这些注释源可以通过模块化插件轻松扩展。内置的导出功能可以生成出版质量的定制蛋白质插图，也适用于大型数据集。表面组数据集的可视化显示了Protter用于膜蛋白的综合可视化分析和靶向蛋白质组学的肽选择的特定实用性。
The ability to integrate and visualize experimental proteomic evidence in the context of rich protein feature annotations represents an unmet need of the proteomics community. Here we present Protter, a web-based tool that supports interactive protein data analysis and hypothesis generation by visualizing both annotated sequence features and experimental proteomic data in the context of protein topology. Protter supports numerous proteomic file formats and automatically integrates a variety of reference protein annotation sources, which can be readily extended via modular plugins. A built-in export function produces publication-quality customized protein illustrations, also for large datasets. Visualizations of surfaceome datasets show the specific utility of Protter for the integrated visual analysis of membrane proteins and peptide selection for targeted proteomics.