New method for direct stiffness measurement of the corpora cavernosa.
New method for direct stiffness measurement of the corpora cavernosa.
复制标题
海绵体直接硬度测量的新方法。
DOI：
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发表时间：
1995
影响因子：
2.6
通讯作者：
C. Constantinou
中科院分区：
文献类型：
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作者：
D. Hatzichristou;S. Omata;C. Constantinou
我们描述了一种直接体外测量躯体僵硬的新方法。使用一种新型生物传感器，测量了32只成年雄性Spraque Dawley大鼠的海绵体硬度。平均硬度(+/-Se)值为8.186+/-0.318 gm/cm。与膀胱和前列腺相比，语体在数量上是最硬的器官。在两个语料库的不同点上测量的值显示出相当均匀的硬度(范围为7.576-8.835克/厘米)。激素刺激显示，DHT可显著增加前列腺硬度，但不能显著增加体部硬度。同样，α-肾上腺素能拮抗剂对躯体僵硬的影响在统计学上没有显着意义。这些结果表明，激素和肾上腺素能刺激对语料库的被动特性的影响可以忽略不计。结果表明，该方法为人体刚度的测量提供了一种可重复使用的新参数。预计在未来，这种僵硬测量可能用于评估在体骨小梁平滑肌张力的生物力学特性及其对药物处理的反应。
We describe a new methodology for direct ex vivo measurements of corporal stiffness. Using a new biosensor, stiffness of the corpora cavernosa was measured in 32 mature male Spraque Dawley rats. Mean stiffness (+/- se) value of the corpora was 8.186 +/- 0.318 gm/cm. The corpora was numerically the stiffest organ, when compared to the bladder and the prostate. Values measured at different points from both corpora showed a quite uniform stiffness (range 7.576-8.835 gm/cm). Hormonal stimulation with DHT was shown to significantly increase prostatic stiffness but not corpora stiffness. Similarly alpha-adrenergic antagonists did not affect corporal stiffness in a statistically significant manner. These results suggest that the influence of hormones and adrenergic stimulation on the passive properties of the corpora is negligible. It is concluded that this new method provides a reproducible new parameter for the measurement of corporal stiffness. It is anticipated that in the future this kind of stiffness measurement may be of use for the evaluation of the biomechanical properties of the corpora and its response to pharmacologic manipulation of the trabecular smooth muscle tone in vivo.