A Novel Method for Calculating Potency-Weighted Cumulative Phthalates Exposure with Implications for Identifying Racial/Ethnic Disparities among U.S. Reproductive-Aged Women in NHANES 2001-2012.
A Novel Method for Calculating Potency-Weighted Cumulative Phthalates Exposure with Implications for Identifying Racial/Ethnic Disparities among U.S. Reproductive-Aged Women in NHANES 2001-2012.
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一种计算效力加权累积邻苯二甲酸盐暴露量的新方法，对识别 NHANES 2001-2012 中美国育龄妇女的种族/民族差异具有影响。
DOI：
10.1021/acs.est.6b00522
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发表时间：
2016
影响因子：
11.4
通讯作者：
Woodruff,TraceyJ
中科院分区：
文献类型：
--
作者：
Varshavsky,JuliaR;Zota,AmiR;Woodruff,TraceyJ
邻苯二甲酸盐是一种无处不在的化学物质，与荷尔蒙紊乱有关，影响生殖和发育。胎儿发育期间多种抗雄激素邻苯二甲酸盐暴露比个体暴露的影响更大；因此，美国国家科学院（NAS）建议对它们进行累积评估。利用2001-2012年全国健康与营养检查调查数据（NHANES， 2001-2012年），我们根据NAS建议，建立了邻苯二甲酸二丁酯（DnBP）、邻苯二甲酸二异丁酯（DiBP）、邻苯二甲酸丁苯酯（BBzP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）的效价加权日摄入量（∑雄激素干扰物；微克/kg/天），并在其他指标（2005-2012年）中包括邻苯二甲酸二乙酯（DEP）和邻苯二甲酸二异壬酯（DiNP）。我们比较了2842名育龄妇女∑雄激素干扰素的种族/民族差异。在敏感性分析中，我们评估了效力假设、替代尿液稀释调整方法和直接加权邻苯二甲酸盐代谢物而不是母体化合物每日摄入量的影响。研究发现，DEHP对∑雄激素干扰因子的贡献最大（48-64%），∑雄激素干扰因子随时间的推移而降低。黑人女性通常比白人女性有更高的累积暴露，尽管差异的大小和精度因模型规格而异。我们的方法为将化学暴露与常见不良后果相结合提供了蓝图，并应在未来的暴露、风险和流行病学研究中加以考虑。
Phthalates are ubiquitous chemicals linked to hormonal disruptions that affect reproduction and development. Multiple antiandrogenic phthalates exposure during fetal development can have greater impacts than individual exposure; thus, the National Academy of Sciences (NAS) recommends them for cumulative assessment. Using National Health and Nutrition Examination Survey data (NHANES, 2001–2012), we developed a potency-weighted sum of daily intake (∑androgen-disruptor; μg/kg/day) of di-n-butyl phthalate (DnBP), diisobutyl phthalate (DiBP), butyl benzyl phthalate (BBzP), and di(2-ethylhexyl) phthalate (DEHP) based on NAS recommendations, and included diethyl phthalate (DEP) and diisononyl phthalate (DiNP) in additional metrics (2005–2012). We compared racial/ethnic differences in ∑androgen-disruptor among 2842 reproductive-aged women. In sensitivity analyses, we assessed the influence of potency assumptions, alternate urine dilution adjustment methods, and weighting phthalate metabolites directly rather than daily intake estimates of parent compounds. We found that DEHP contributed most to ∑androgen-disruptor (48–64%), and that ∑androgen-disruptor decreased over time. Black women generally had higher cumulative exposures than white women, although the magnitude and precision of the difference varied by model specification. Our approach provides a blueprint for combining chemical exposures linked to common adverse outcomes, and should be considered in future exposure, risk, and epidemiological studies.