Epidemiologic observations on eosinophilia and its relation to respiratory disorders.
Epidemiologic observations on eosinophilia and its relation to respiratory disorders.
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DOI：
10.1164/arrd.1980.122.5.709
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发表时间：
2015-05
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影响因子：
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通讯作者：
B. Burrows;F. Hasan;R. Barbee;M. Halonen;M. Lebowitz
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文献类型：
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作者：
B. Burrows;F. Hasan;R. Barbee;M. Halonen;M. Lebowitz
在亚利桑那州图森市的一项普通人群研究中，对2311名受试者的嗜酸性粒细胞百分比（%EOS）进行了测定。在随后的评估中，对290名受试者的亚组进行了更详细的测试，其中获得了绝对嗜酸性粒细胞计数、白细胞计数和鼻嗜酸性粒细胞涂片。在男性中，但在女性中没有，随着年龄的增长，EOS有明显的下降趋势。2月至5月是EOS最高的月份，这是该地区大多数植物开花的时候。血嗜酸性粒细胞与过敏皮肤试验反应性、循环IgE浓度、几种呼吸道症状和疾病诊断以及通气功能降低显著相关。然而，在年龄小于55岁的受试者中，通气功能明显较低，只有当皮肤试验反应性和嗜酸性粒细胞增多时，症状率才会增加。过敏皮肤试验反应性和嗜酸性粒细胞单独与该年龄组的通气功能无关。在老年受试者中，血嗜酸性粒细胞增多与通气功能的明确损害有关，与皮肤试验反应性无关，与吸烟习惯无关。嗜酸性粒细胞增多症的存在确定了一组主要是女性的老年非吸烟者，其通气功能明显受损。这些受试者似乎属于“喘息性支气管炎”的临床范畴。
The percentage of eosinophils (%EOS), determined from a differential blood smear, was measured in 2,311 subjects enrolled in a general population study in Tucson, Arizona. A subgroup of 290 subjects was tested in more detail during a later evaluation in which absolute eosinophil counts, leukocyte counts, and nasal smears for eosinophils were obtained. In men, but not in women, there was a significant tendency for the %EOS to decrease with age. The highest %EOS was noted during the months of February through May, the time when most plants in this region are in bloom. Blood eosinophils were significantly related to allergy skin test reactivity, circulating IgE concentrations, several respiratory symptoms and disease diagnoses, as well as to reduced ventilatory function. Among subjects younger than 55 yr of age, however, ventilatory function was significantly low, and symptom rates increased only when there was allergy skin test reactivity in addition to eosinophilia. Neither allergy skin test reactivity nor eosinophilia alone was related to ventilatory function in this age group. Among older subjects, blood eosinophilia was associated with definite impairment of ventilatory function, regardless of skin test reactivity and independent of smoking habits. The presence of eosinophilia identified a predominantly female group of elderly nonsmokers with markedly impaired ventilatory function. These subjects appeared to fall into the clinical category of "asthmatic bronchitis".