The influence of maternal smoking habits on the risk of subsequent stillbirth: is there a causal relation?

The influence of maternal smoking habits on the risk of subsequent stillbirth: is there a causal relation?
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DOI:
10.1111/j.1471-0528.2007.01340.x
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发表时间:
2007-06
期刊:
BJOG : an international journal of obstetrics and gynaecology
影响因子:
--
通讯作者:
Cnattingius S
Cnattingius S
中科院分区:
其他
文献类型:
--
作者:
Högberg L;Cnattingius S

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此前,母亲吸烟曾被认为与死产风险有关。如果戒烟的女性能够降低死产的风险,那么因果关系的假设就会得到支持。前瞻性队列研究。在瑞典全国学习。 1983 年至 2001 年间连续生育第一胎和第二胎的初产妇女总数为 526 691 名。一项以人口为基础的瑞典研究,数据来自医疗出生登记处、移民登记处和教育登记处。使用逻辑回归分析来估计比值比,使用 95% 置信区间。第二次怀孕时死产。与两次怀孕期间不吸烟的女性相比,第一次怀孕期间吸烟但第二次怀孕期间不吸烟的女性死产风险并未增加(OR 1.02;95% CI 0.79–1.30),而两次怀孕期间吸烟的女性相应风险为1.35(95% CI 1.15–1.58)。结果表明,母亲在怀孕期间吸烟与死产风险存在因果关系。吸烟是死产的一个可预防的原因,吸烟干预是产前护理中的一个重要问题。
Maternal smoking has previously been associated with risk of stillbirth. If women who quit smoking reduce their risk of stillbirth, the hypothesis of a causal association would be supported. Prospective cohort study. Nationwide study in Sweden. All primiparous women who delivered their first and second consecutive single births between 1983 and 2001, giving a total number of 526 691 women. A population-based Swedish study with data from the Medical Birth Registry, the Immigration Registry and the Education Registry. Logistic regression analyses were used to estimate odds ratios, using 95% confidence intervals. Stillbirth in the second pregnancy. Compared with nonsmokers in both pregnancies, women who smoked during the first pregnancy but not during the second do not have an increased risk of stillbirth (OR 1.02; 95% CI 0.79–1.30), while corresponding risk among women who smoked during both pregnancies was 1.35 (95% CI 1.15–1.58). The result supports that maternal smoking during pregnancy is causally associated with stillbirth risk. Smoking is a preventable cause of stillbirth, and smoking interventions is an important issue in antenatal care.
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