Benzodiazepine anti-conflict effects in Maudsley reactive (MR/Har) and non-reactive (MNRA/Har) rats.
Benzodiazepine anti-conflict effects in Maudsley reactive (MR/Har) and non-reactive (MNRA/Har) rats.
复制标题
苯二氮卓类药物对莫兹利反应性 (MR/Har) 和非反应性 (MNRA/Har) 大鼠的抗冲突作用。
DOI：
10.1007/bf02244595
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发表时间：
1990
影响因子：
3.4
通讯作者：
Altman,HJ
中科院分区：
文献类型：
--
作者：
Commissaris,RL;Harrington,GM;Altman,HJ
Maudsley 反应性 (MR/Har) 和非反应性 (MNRA/Har) 大鼠品系最初由布罗德赫斯特 (Broadhurst) 培育，因为它们在露天排便方面存在差异，它们在条件性抑制饮酒 (CSD) 冲突程序中的控制（即非药物）行为也有所不同，CSD 是研究大鼠焦虑和/或情绪的第二种“模型”行为。本研究比较了地西泮和阿普唑仑对这两种大鼠 CSD 行为的影响。在每天 10 分钟的训练中，缺水的老鼠被训练从偶尔通电 (0.2-0.5 mA) 的管子里喝水，通电时会发出声音信号。地西泮和阿普唑仑都以剂量相关的方式增加惩罚反应。两种菌株的惩罚反应增加百分比（仅适用于地西泮）相当；然而，统计和经验方法均表明，MNRA/Har 与 MR/Har 大鼠中苯二氮卓类药物抗冲突作用的大小与基线（即非药物）惩罚反应的差异无关。根据所接受电击的绝对变化，MNRA/Har品系的大鼠在地西泮或阿普唑仑治疗后表现出比MR/Har品系的大鼠显着更强的抗冲突作用。这些发现进一步提出这样的假设：Maudsley MR/Har 和 MNRA/Har 大鼠品系表现出的行为差异可能构成用于情绪和/或焦虑研究的基于基因的“动物模型”。
The Maudsley Reactive (MR/Har) and Non-Reactive (MNRA/Har) rat strains, bred originally by Broadhurst for differences in Open Field Defecation, also differ in their control (i.e., non-drug) behavior in the Conditioned Suppression of Drinking (CSD) conflict procedure, a second “model” behavior for the study of anxiety and/or emotionality in rats. The present studies compared the effects of diazepam and alprazolam on CSD behavior in these two strains of rats. In daily 10-min sessions, water-deprived rats were trained to drink from a tube that was occasionally electrified (0.2–0.5 mA), electrification being signaled by a tone. Both diazepam and alprazolam increased punished responding in a dose-related manner. The per cent increase in punished responding (for diazepam only) was comparable in the two strains; however, both statistical and empirical approaches indicated that the magnitude of the anti-conflict effect of benzodiazepines in MNRA/Har versus MR/Har rats was not related to differences in baseline (i.e., non-drug) punished responding. Based on the absolute change in shocks received, rats of the MNRA/Har strain exhibited a significantly greater anti-conflict effect following diazepam or alprazolam treatment than did rats of the MR/Har strain. These findings further the hypothesis that the behavioral differences exhibited by Maudsley MR/Har and MNRA/Har rat strains may constitute a genetically-based “animal model” for the study of emotionality and/or anxiety.