Statin treatment and adherence to national cholesterol guidelines after ischemic stroke
Statin treatment and adherence to national cholesterol guidelines after ischemic stroke
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DOI：
10.1212/01.wnl.0000208403.18885.0e
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发表时间：
2006-04-25
期刊：
影响因子：
9.9
通讯作者：
Crouse, JR
中科院分区：
文献类型：
--
作者：
Ovbiagele, B;Saver, JL;Crouse, JR
背景：国家胆固醇指南将高危人群定义为那些可能从他汀类药物治疗中获益最多的人。作者旨在确定他汀类药物的使用率，其预测因素，以及缺血性卒中幸存者中国家指南目标脂质目标的实现。方法：作者从美国和加拿大的维生素干预预防中风（VISP）研究数据库中提取数据，根据国家胆固醇教育计划（NCEP）高危人群指南，纳入他汀类药物治疗的启动算法。作者将这些算法应用于所有研究对象。然后利用相关的人口统计学、临床和实验室数据评估目标脂质水平和他汀类药物实施的单变量和多变量关联。结果：在分析数据集中的2894名受试者中，38%为女性；71%在美国招募，29%在加拿大招募。在769名高风险受试者中，262名（34%）低密度脂蛋白（LDL）水平>= 130 mg/dL，其中124名（47%）未服用他汀类药物。在接受他汀类药物治疗的高危人群中，只有42%的人有低密度脂蛋白
Background: National cholesterol guidelines have defined high vascular risk individuals as those who could potentially benefit most from statin therapy. The authors aimed to determine the rate of statin use, its predictors, and the achievement of national guideline target lipid goals among ischemic stroke survivors. Methods: The authors abstracted data from the Vitamin Intervention for Stroke Prevention (VISP) study database from the United States and Canada to incorporate into algorithms for initiating statin therapy according to the National Cholesterol Education Program (NCEP) guidelines for high-risk individuals. The authors applied these algorithms to all study subjects. Univariate as well as multivariate associations for target lipid levels and statin implementation were then evaluated utilizing pertinent demographic, clinical, and laboratory data. Results: Of 2,894 subjects in the analysis dataset, 38% were women; 71% were recruited in the United States and 29% in Canada. Of 769 high-risk subjects, 262 (34%) had a low-density lipoprotein (LDL) level >= 130 mg/dL and 124 of these (47%) were not on statin. Among those high-risk persons on statin treatment, only 42% had an LDL